Original ArticlesSystemic Complications of COVID-19Ashraf, Obaid MD; Young, Meilin MD; Malik, Khalid J. MD; Cheema, Tariq MDAuthor Information Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania. Correspondence: Tariq Cheema, MD, Division of Pulmonary Critical Care Medicine, Allegheny General Hospital, Pulmonary Lab, 320 East North Ave, Pittsburgh, PA 15212 ([email protected]). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Critical Care Nursing Quarterly: October/December 2020 - Volume 43 - Issue 4 - p 390-399 doi: 10.1097/CNQ.0000000000000324 Buy Metrics Abstract Coronavirus disease-2019 (COVID-19) creates severe respiratory distress and often a cascade of other systemic complications impacting several organ systems. The immune response includes a cytokine storm that creates many life-threatening problems including coagulopathies, arrhythmias, and secondary infections. This article discusses the multisystem responses to the physical insults created by this corona virus. © 2020 Wolters Kluwer Health, Inc. All rights reserved.