Original ArticleThe Use of Hypertonic Saline for Fluid Resuscitation in Sepsis A ReviewSingh, Anil MD; Carlin, Brian W. MD; Shade, Daniel MD; Kaplan, Peter D. MDAuthor Information Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania. Corresponding Author: Anil Singh, MD, Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212. Critical Care Nursing Quarterly: January 2009 - Volume 32 - Issue 1 - p 10-13 doi: 10.1097/01.CNQ.0000343128.81576.dd Buy Metrics Abstract Early volume resuscitation of a patient with sepsis has been shown to reduce morbidity, mortality, and healthcare resource consumption. Hypertonic saline offers a theoretically viable option for volume resuscitation. This article reviews the current information available regarding fluid resuscitation in patients with sepsis, with emphasis on the use of hypertonic saline. © 2009 Lippincott Williams & Wilkins, Inc.