ArticleNew Technology Applications Thrombolysis of Acute Deep Vein ThrombosisMarchigiano, Gail MSN, CCRN; Riendeau, Debra MN, APRN, BC; Jo Morse, Carol BSN, CMSRN Author Information Saint Joseph's College of Maine, Standish (Mss Marchigiano and Riendeau); and Maine Medical Center CN III and Vascular Nursing Committee, Portland (Ms Morse). Corresponding author: Gail Marchigiano, MSN, CCRN, 278 Whites Bridge Rd, Standish, ME 04084 (e-mail: [email protected]). Critical Care Nursing Quarterly: October 2006 - Volume 29 - Issue 4 - p 312-323 Buy CE Test Abstract Treatment of deep vein thrombosis traditionally has focused on preventing the potentially life-threatening complication of pulmonary embolism rather than on removing or reducing the thrombus. Although treatment with anticoagulants may prevent thrombus propagation, the body's intrinsic thrombolytic system is left to attempt clot dissolution. Because this natural process is generally ineffective in its ability to fully recanalize a proximal vein, the risks of recurrent thrombosis as well as the disabling complication of postthrombotic syndrome increase. Moreover, the long-term consequences of postthrombotic syndrome include pain, disability, and, for many, a significant decrease in the quality of life. Recent technology using high-frequency, low-power ultrasound, or mechanical thrombectomy with catheter-directed delivery of a thrombolytic drug directly into the clot is available and showing promise. Nurses are caring for patients who receive endovascular interventions with lytic infusions. The nursing challenge is to provide safe and effective patient care. © 2006 Lippincott Williams & Wilkins, Inc.