ArticlesImmune System Modulation in the Highly Sensitized Transplant CandidateDavidson, Beth Towery MSN, ACNP; Donaldson, Terri Allison MN, ACNPAuthor Information From the Vanderbilt University Medical Center and Vanderbilt University School of Nursing, Nashville, Tenn. The authors thank Larry E. Lancaster, EdD, ACNP, for his mentorship and editorial assistance with the manuscript. Corresponding author: Terri A. Donaldson, MN, ACNP, 128 Northlake Dr, Hendersonville, TN 37075 (e-mail: [email protected]). Critical Care Nursing Quarterly: January 2004 - Volume 27 - Issue 1 - p 1-9 Buy Abstract Heart transplantation can be a lifesaving option for patients with end-stage heart failure. However, implanting recipients with an organ or tissue from a donor presents immunologic challenges. Sensitized recipients are at risk for hyperacute rejection because of the presence of preformed antibodies. Immune modulation with cyclophosphamide, plasmapheresis, and intravenous gamma globulin are methods used to desensitize transplant candidates with preformed anti-HLA antibodies to achieve successful transplantation. © 2004 Lippincott Williams & Wilkins, Inc.