Critical Care Research: Part 1Desaturation Events in Neonates during Mechanical VentilationShiao, Shyang-Yun Pamela K. PhD, RNAuthor Information Associate Professor, School of Nursing, The University of Texas Health Science Center—Houston, Houston, Texas This study was supported by multiple funding sources: (1) Dean's pilot research awards (1995–1997) at Frances Payne Bolton School of Nursing, (2) research initiation grant (1995–1996) at Case Western Reserve University, (3) Abbott Critical Care Cleveland local vendor representatives (1995), (4) KCI-AACN critical care research award from the American Association of Critical Care Nurses (1995–1996), (5) research award from the Foundation for Neonatal Research and Education, National Association of Neonatal Nurses, and (6) the National Institutes of Health, National Institute of Nursing Research, R55-NR04447. Special appreciation is extended to the research students at Frances Payne Bolton School of Nursing and families and clinicians who participated in this pilot study at Rainbow Babies and Children's Hospital of Cleveland. Critical Care Nursing Quarterly: February 2002 - Volume 24 - Issue 4 - p 14-29 Buy Abstract This study examines the accuracy of oxygen saturation measured by Nellcor N200 pulse oximetry (SpO2) compared with arterial oxygen saturation (SaO2) measured through a three-wavelength fiberoptic umbilical catheter in 10 neonates who needed mechanical ventilation. Real-time SaO2 was validated with a reference method every 4 hours. Oxygen saturation readings (SaO2 and SpO2), along with pulse rate and pulsation, were recorded continuously every second through a computer. Concurrent care events and neonatal responses were recorded. Data were completed on 10 neonates who had an umbilical arterial catheter. Desaturation events (<90%) as measured by both SaO2 and SpO2 were described and compared. A total of 959 desaturation events occurred during an average of 51 hours of monitoring per subject. Of these events, 63% were associated with frozen SpO2 readings, and 18% of frozen readings occurred when SaO2 was <90%. Bias for SpO2 compared with SaO2 was +5.03%, with 5.6% of the readings outside the range of two standard deviations. However, 67% of the readings exceeded the 4% difference criterion between measurements. Future studies need to examine the desaturation events in relation to oxygenation status as measured by different methods. Copyright © 2002 by Aspen Publishers, Inc.