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Latest Articles are available in PDF format only.

Clinical Investigation

Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19

Rocheleau, Genevieve L. Y.; Lee, Terry; Mohammed, Yassene; More

May 19, 2022

Clinical Investigation

A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation

Lonze, Bonnie E.; Spiegler, Peter; Wesson, Russell N.; More

May 18, 2022

Clinical Investigation

Patient, Public, and Healthcare Professional’s Sepsis Awareness, Knowledge, and Information Seeking Behaviors: A Scoping Review

Fiest, Kirsten M.; Krewulak, Karla D.; Brundin-Mather, Rebecca; More

April 29, 2022

Online Clinical Investigation

The Impact of a Machine Learning Early Warning Score on Hospital Mortality: A Multicenter Clinical Intervention Trial

Winslow, Christopher J.; Edelson, Dana P.; Churpek, Matthew M.; More

April 22, 2022

Clinical Investigation

Persistent But Not Transient Acute Kidney Injury Was Associated With Lower Transplant-Free Survival in Patients With Acute Liver Failure: A Multicenter Cohort Study

Cardoso, Filipe S.; Fidalgo, Pedro; Bagshaw, Sean M.; More

April 21, 2022

Clinical Investigation

The Impact of Health Information Technology for Early Detection of Patient Deterioration on Mortality and Length of Stay in the Hospital Acute Care Setting: Systematic Review and Meta-Analysis

Herasevich, Svetlana; Lipatov, Kirill; Pinevich, Yuliya; More

April 12, 2022

Clinical Investigation

Early Neuromuscular Electrical Stimulation in Addition to Early Mobilization Improves Functional Status and Decreases Hospitalization Days of Critically Ill Patients

Campos, Débora R.; Bueno, Thatiana B. C.; Anjos, Jackeline S. G. G.; More

April 12, 2022

Clinical Investigation

The Feasibility of Implementing Targeted SEDation in Mechanically Ventilated Emergency Department Patients: The ED-SED Pilot Trial

Fuller, Brian M.; Roberts, Brian W.; Mohr, Nicholas M.; More

April 11, 2022

Clinical Investigation: PDF Only

The Use and Duration of Preintubation Respiratory Support Is Associated With Increased Mortality in Immunocompromised Children With Acute Respiratory Failure

Lindell, Robert B.; Fitzgerald, Julie C.; Rowan, Courtney M.; More

March 14, 2022

Online Letter to the Editor: PDF Only

The authors reply

Burnim, Michael S.; Wang, Kunbo; Checkley, William; More

March 08, 2022

Clinical Investigation: PDF Only

A Retrospective Observational Study Exploring 30- and 90-Day Outcomes for Patients With COVID-19 After Percutaneous Tracheostomy and Gastrostomy Placement

Kiser, Stephanie B.; Sciacca, Kate; Jain, Nelia; More

February 21, 2022

Clinical Investigation: PDF Only

Sleep and Circadian Health of Critical COVID-19 Survivors 3 Months After Hospital Discharge

Benítez, Iván D.; Moncusí-Moix, Anna; Vaca, Rafaela; More

February 18, 2022

Online Clinical Investigation: PDF Only

Acquired Von Willebrand Syndrome and Desmopressin Resistance During Venovenous Extracorporeal Membrane Oxygenation in Patients With COVID-19: A Prospective Observational Study

Kalbhenn, Johannes; Glonnegger, Hannah; Büchsel, Martin; More

February 18, 2022

Online Laboratory Investigation: PDF Only

The β1-Adrenergic Receptor Contributes to Sepsis-Induced Immunosuppression Through Modulation of Regulatory T-Cell Inhibitory Function

Durand, Manon; Hagimont, Eugénie; Louis, Huguette; More

February 18, 2022

Clinical Investigation: PDF Only

Educational Outcomes of Childhood Survivors of Critical Illness—A Population-Based Linkage Study

Tomaszewski, Wojtek; Ablaza, Christine; Straney, Lahn; More

February 15, 2022

Clinical Investigation: PDF Only

Ventilator-Associated Lower Respiratory Tract Bacterial Infections in COVID-19 Compared With Non-COVID-19 Patients

Hedberg, Pontus; Ternhag, Anders; Giske, Christian G.; More

February 14, 2022

Clinical Investigation: PDF Only

Effects of Prone Position on Lung Recruitment and Ventilation-Perfusion Matching in Patients With COVID-19 Acute Respiratory Distress Syndrome: A Combined CT Scan/Electrical Impedance Tomography Study

Fossali, Tommaso; Pavlovsky, Bertrand; Ottolina, Davide; More

February 11, 2022

Online Clinical Investigation: PDF Only

Lung-Dependent Areas Collapse, Monitored by Electrical Impedance Tomography, May Predict the Oxygenation Response to Prone Ventilation in COVID-19 Acute Respiratory Distress Syndrome

Cardinale, Michael; Boussen, Salah; Cungi, Pierre-Julien; More

February 11, 2022

Clinical Investigation: PDF Only

Early Clinical and Electrophysiological Brain Dysfunction Is Associated With ICU Outcomes in COVID-19 Critically Ill Patients With Acute Respiratory Distress Syndrome: A Prospective Bicentric Observational Study

Benghanem, Sarah; Cariou, Alain; Diehl, Jean-Luc; More

February 09, 2022

Clinical Investigation: PDF Only

CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot Study

Stockmann, Helena; Thelen, Philipp; Stroben, Fabian; More

February 09, 2022

Online Clinical Investigation: PDF Only

Factors Associated With Brain Tissue Oxygenation Changes After RBC Transfusion in Acute Brain Injury Patients

Gouvêa Bogossian, Elisa; Rass, Verena; Lindner, Anna; More

February 08, 2022

Online Clinical Investigation: PDF Only

Neurologic Outcomes of Survivors of COVID-19–Associated Acute Respiratory Distress Syndrome Requiring Intubation

Jaquet, Pierre; Legouy, Camille; Le Fevre, Lucie; More

February 08, 2022

Online Clinical Investigation: PDF Only

Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury

Steinberg, Irene; Pasticci, Iacopo; Busana, Mattia; More

February 08, 2022

Online Clinical Investigation: PDF Only

Relative Hypoglycemia and Lower Hemoglobin A1c-Adjusted Time in Band Are Strongly Associated With Increased Mortality in Critically Ill Patients

Krinsley, James S.; Rule, Peter R.; Roberts, Gregory W.; More

February 08, 2022

Clinical Investigation: PDF Only

Association of Metformin Use During Hospitalization and Mortality in Critically Ill Adults With Type 2 Diabetes Mellitus and Sepsis

Gómez, Hernando; Del Rio-Pertuz, Gaspar; Priyanka, Priyanka; More

February 07, 2022

Review Article: PDF Only

Low Tidal Volume Ventilation for Emergency Department Patients: A Systematic Review and Meta-Analysis on Practice Patterns and Clinical Impact

De Monnin, Karlee; Terian, Emily; Yaegar, Lauren H.; More

February 07, 2022

Online Clinical Investigation: PDF Only

The Effect of Clusters of Double Triggering and Ineffective Efforts in Critically Ill Patients

Magrans, Rudys; Ferreira, Francini; Sarlabous, Leonardo; More

February 07, 2022

Online Brief Report: PDF Only

Herpes Simplex Virus Encephalitis With Initial Negative Polymerase Chain Reaction in the Cerebrospinal Fluid: Prevalence, Associated Factors, and Clinical Impact

de Montmollin, Etienne; Dupuis, Claire; Jaquet, Pierre; More

February 02, 2022

Online Clinical Investigation: PDF Only

Longitudinal Trends in Bleeding Complications on Extracorporeal Life Support Over the Past Two Decades—Extracorporeal Life Support Organization Registry Analysis

Willers, Anne; Swol, Justyna; Buscher, Hergen; More

February 02, 2022

Clinical Investigation: PDF Only

Patient-Centered Outcomes Following COVID-19: Frailty and Disability Transitions in Critical Care Survivors

Taniguchi, Leandro Utino; Avelino-Silva, Thiago Junqueira; Dias, Murilo Bacchini; More

January 26, 2022

Online Clinical Investigation: PDF Only

Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance

Mukherjee, Riddhita; Tompkins, Carly A.; Ostberg, Nicolai P.; More

January 24, 2022

Online Clinical Investigation: PDF Only

A Minimally Invasive and Highly Effective Extracorporeal CO2 Removal Device Combined With a Continuous Renal Replacement Therapy

Zanella, Alberto; Pesenti, Antonio; Busana, Mattia; More

January 18, 2022

Online Clinical Investigation: PDF Only

Platelet Phenotype and Function Changes With Increasing Duration of Extracorporeal Membrane Oxygenation

Van Den Helm, Suelyn; Yaw, Hui Ping; Letunica, Natasha; More

January 12, 2022

Online Clinical Investigation: PDF Only

Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome

Seeliger, Benjamin; Doebler, Michael; Hofmaenner, Daniel Andrea; More

January 12, 2022

Online Clinical Investigation: PDF Only

Brain Biopsy for Neurological Diseases of Unknown Etiology in Critically Ill Patients: Feasibility, Safety, and Diagnostic Yield

Mathon, Bertrand; Favreau, Malory; Degos, Vincent; More

January 10, 2022

Online Clinical Investigation: PDF Only

Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network

Azimaraghi, Omid; Wongtangman, Karuna; Wachtendorf, Luca J.; More

January 05, 2022

Clinical Investigation: PDF Only

Patient Heterogeneity and the J-Curve Relationship Between Time-to-Antibiotics and the Outcomes of Patients Admitted With Bacterial Infection

Usher, Michael G.; Tourani, Roshan; Webber, Ben; More

December 31, 2021

Online Clinical Investigation: PDF Only

Outcome of Temporary Circulatory Support As a Bridge-to-Left Ventricular Assist Device Strategy in Cardiogenic Shock Patients

Bidaut, Auriane; Flécher, Erwan; Nesseler, Nicolas; More

December 31, 2021

Online Clinical Investigation: PDF Only

Impact of the Coronavirus Disease 2019 Pandemic on Moral Distress Among Nurses and Physicians in Spanish ICUs

Rodriguez-Ruiz, Emilio; Campelo-Izquierdo, Maitane; Boga Veiras, Paula; More

December 29, 2021

Clinical Investigation: PDF Only

Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome

Lim, Michelle J.; Zinter, Matt S.; Chen, Lucia; More

October 25, 2021

Online Clinical Investigation: PDF Only

Simulation Versus Interactive Mobile Learning for Teaching Extracorporeal Membrane Oxygenation to Clinicians: A Randomized Trial

Gannon, Whitney D.; Stokes, John W.; Pugh, Meredith E.; More

October 22, 2021

Review Article: PDF Only

Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults

Hines, Melissa R.; von Bahr Greenwood, Tatiana; Beutel, Gernot; More

October 05, 2021

Clinical Investigation: PDF Only

Coronavirus Disease 2019 and Out-of-Hospital Cardiac Arrest: No Survivors

Baert, Valentine; Beuscart, Jean-Baptiste; Recher, Morgan; More

October 01, 2021

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