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A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

Vincent, Jean-Louis MD, PhD, FCCM1; Ramesh, Mayakonda K. MS2; Ernest, David MBBS3; LaRosa, Steven P. MD4; Pachl, Jan MD, PhD5; Aikawa, Naoki MD, DMSc, FACS6; Hoste, Eric MD, PhD7; Levy, Howard MB, BCh, PhD8; Hirman, Joe PhD9; Levi, Marcel MD, PhD10; Daga, Mradul MD, FCCP11; Kutsogiannis, Demetrios J. MD, MHS12; Crowther, Mark MD, MSc, FRCPC13; Bernard, Gordon R. MD14; Devriendt, Jacques MD15; Puigserver, Joan Vidal MD16; Blanzaco, Daniel U. MD17; Esmon, Charles T. PhD18; Parrillo, Joseph E. MD19; Guzzi, Louis MD, FCCM20; Henderson, Seton J. MB, ChB21; Pothirat, Chaicharn MD, FCCP22; Mehta, Parthiv MD23; Fareed, Jawed PhD, FAHA24; Talwar, Deepak MD, DM, DNB25; Tsuruta, Kazuhisa PhD26; Gorelick, Kenneth J. MD, FCCP27; Osawa, Yutaka MPharm26; Kaul, Inder MD, MPH26

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doi: 10.1097/CCM.0b013e31828e9b03
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Abstract

© 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins