1Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.
2IRCCS San Martino IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
3Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
4Institute of Nuclear Medicine, University Hospital Dresden, Dresden, Germany.
5Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard University, Boston, MA.
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Dr. Güldner, Ms. Braune, and Dr. Ball equally contributed to this article. All authors contributed to the conception and/or design of this study. Dr. Güldner, Ms. Braune, Dr. Ball, Dr. Silva, Ms. Samary, Dr. Insorsi, Ms. Becker, and Dr. Andreeff contributed to the acquisition of data. Ms. Braune, Dr. Ball, Mr. Huhle, Dr. Rentzsch, and Dr. Oehme contributed to data processing. All authors contributed to the analysis and interpretation of data. Dr. Güldner, Ms. Braune, Dr. Pelosi, and Dr. Gama de Abreu drafted the article, and all authors critically revised it for important intellectual content and approved the final version to be submitted.
Supported by a grant of the MeDDrive Program, Medical Faculty Carl Gustav Carus, Dresden, Germany. The positron emission tomography/computed tomography device was a gift from the German Federal Ministry of Education and Research (BMBF contract 03ZIK42/OncoRay), Bonn, Germany.
This work was performed by the Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, and the Institute of Nuclear Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Ms. Braune disclosed work for hire. Mr. Huhle disclosed work for hire. Dr. Vidal Melo received support for article research from the National Institutes of Health (NIH). His institution received grant support from RO1 HL 121228, NIH, and Merck (current investigator-initiated grant from Merck). Dr. Kotzerke’s institution received grant support from Deutsche Forschungsgemeinschaft. Dr. Gama de Abreu served as a board member for Ventinova EV (Eindhoven, The Netherlands); consulted for Dräger Medical AG (Lübeck, Germany) and Novalung GmbH (Heilbronn, Germany); lectured for Dräger Medical AG (Lübeck, Germany), Novalung GmbH (Heilbronn, Germany), and GE Healthcare (Paris, France); received support for the development of educational presentations from Dräger Medical AG (Lübeck, Germany); received support for travel from Dräger Medical AG (Lübeck, Germany), Novalung GmbH (Heilbronn, Germany), and GE Healthcare (Paris, France); and received support for article preparation from Dräger Medical AG (Lübeck, Germany). His institution received grant support from the German Research Foundation (Governmental Institution; research grant). The remaining authors have disclosed that they do not have any potential conflicts of interest.
Address requests for reprints to: Dr. Marcelo Gama de Abreu, MD, MSc, PhD, DESA, Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. E-mail: [email protected]
