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Extracorporeal Membrane Oxygenation for Septic Shock

Falk, Lars MD1,2; Hultman, Jan MD, PhD1,2; Broman, Lars Mikael MD, PhD1,2

doi: 10.1097/CCM.0000000000003819
Clinical Investigations
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Objectives: Septic shock carries a high mortality risk. Studies have indicated that patients with septic shock may benefit from extracorporeal membrane oxygenation. In most studies, patients exhibited shock due to myocardial dysfunction rather than distributive/vasoplegic shock. One proposed theory is that venoarterial extracorporeal membrane oxygenation alleviates a failing myocardial function.

Design: Retrospective observational study.

Setting: Single-center, high-volume extracorporeal membrane oxygenation unit.

Patients: All patients treated for septic shock between 2012 and 2017 with an age greater than 18 years old, fulfilling septic shock criteria according to “Sepsis-3” at acceptance for extracorporeal membrane oxygenation, presence of cardiocirculatory failure requiring a support equivalent to a Vasoactive Inotropic Score greater than 50 to reach a mean arterial pressure greater than 65 mm Hg despite adequate fluid resuscitation, were included.

Interventions: None.

Measurements and Main Results: Thirty-seven patients, mean age 54.7 years old, were included. Median Simplified Acute Physiology Score-3 score was 86 and Sequential Organ Failure Assessment 16. Twenty-seven patients were submitted to venoarterial and 10 patients to venovenous extracorporeal membrane oxygenation. Hospital survival was 90% for septic shock with left ventricular failure and 64.7% in patients with distributive shock. At long-term follow-up at 46.1 months, total survival was 59.5%. Commencement of venovenous extracorporeal membrane oxygenation and more organ failures at admission showed a less favorable outcome in terms of hospital and long-term survival.

Conclusions: The current results add not only to the growing evidence of the benefit of venoarterial extracorporeal membrane oxygenation for septic cardiomyopathy but also indicate improved hospital survival in distributive septic shock.

1ECMO Centre Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.

2Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).

Dr. Falk is a member of Extracorporeal Life Support Organization (ELSO, Ann Arbor, MI) Education group. Dr. Broman has received honoraria from Eurosets Srl, Medolla, Italy; Xenios, Heilbronn, Germany, for Medical Advisory Board consultancies; Maquet Getinge, Solna, Sweden; and Evolan Pharma, Danderyd, Sweden. He is a member of the independent research consortium European Extracorporeal Membrane Oxygenation (ECMO) Advisory Board, the EuroELSO Working Group for Innovation of Technology, the EuroELSO Scientific Committee, the ELSO Workgroup for Adult ECMO, and the ELSO Registry. Dr. Hultman has disclosed that he does not have any potential conflicts of interest.

For information regarding this article, E-mail: lars.falk@ sll.se

Septic shock is known to have a high mortality rate and carries the highest risk of death in intensive care (1). Albeit the increasing number of extracorporeal membrane oxygenation (ECMO) treatments, ECMO is not considered a standard treatment for adult patients with septic shock (23) as opposed to the pediatric and neonatal populations (3–6). Even though ECMO has gained increased acceptance for treatment of adult severe respiratory failure, the controversy remains concerning its usefulness in septic shock (27). During the last years, several publications question this standpoint (8–11) and indications emerge that ECMO may be performed with mortality rates comparable to or better than conventional treatment (12). Bréchot et al (8) reported a 70% survival rate and low post-ECMO mortality compared with a reference cohort. However, others have reported worse outcome especially in combination with extracorporeal cardiopulmonary resuscitation (ECPR) (1011).

This retrospective study was undertaken to describe a septic shock population with a combination of acute respiratory distress syndrome and cytotoxic cardiac failure or distributive shock submitted to ECMO treatment at a high-volume ECMO center.

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MATERIALS AND METHODS

Setting

Our center is a high-volume ECMO unit treating approximately 90 respiratory and cardiac ECMO patients per year. The unit is an Extracorporeal Life Support Organization (Ann Arbor, MI) member since 1992 and Center of Excellence since 2007. Population served is 10 million (Sweden, all age groups). We also support Finland and Ireland concerning neonatal and pediatric respiratory ECMO. Hence, an ECMO transport organization is integrated with the department. Approximately 80% of the patients are referred from other hospitals, assessed and cannulated at the referring hospital, and then transferred to our unit after commencement of ECMO (1314).

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Indications

Indications for ECMO may be either respiratory and/or circulatory. Septic shock should be considered for referral to an ECMO center experienced in treating septic shock (815). In our department, respiratory support (i.e., venovenous ECMO) is offered if the Pao2-to-Fio2 ratio is less than 60–80 mm Hg (Fio2 1.0), that is, the resource is used as rescue treatment when conventional respiratory critical care fails. Venoarterial ECMO for cardiocirculatory support is considered after adequate fluid resuscitation together with at least one of the following criteria: persistent lactatemia greater than 5 mmol/L, mixed venous saturation (Svo2) less than 55%, or cardiac index less than 2 L/min/m2 (> 1 hr), rapidly deteriorating ventricular function, refractory arrhythmia, Vasoactive Inotropic Score (VIS) greater than 50 (> 1 hr), greater than 45 (> 8 hr), or greater than 40 if myocarditis. VIS (1617) was calculated as ([(epinephrine + norepinephrine) μg/kg/min] × 100 + [(dobutamine + dopamine) μg/kg/min] + [milrinone μg/kg/min] × 15 + [vasopressin IU/kg/min] × 10,000). Echocardiography was performed in all patients before cannulation.

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Equipment/Supplies

The ECMO pumps used were Centrimag (St. Jude Medical Europe, Zaventem, Belgium) or Cardiohelp (Maquet Cardiopulmonary AG, Rastatt, Germany). All cannulations were peripheral, performed by a dedicated ECMO surgeon. The drainage configuration applied was adapted to minimize differential hypoxemia in venoarterial ECMO (1819). Bio-Medicus 19–21F/18 cm, 23F/25 cm, 17–29F/50 cm (Medtronic International Trading Sàrl, Tolochenaz, Switzerland), or 25F/38 cm Maquet HLS (Maquet Cardiopylmonary AG, Rastatt, Germany) was used in both venovenous and venoarterial ECMO and implanted via the right jugular vein. The oxygenated blood was returned via a femoral vessel with a 15F/17 cm, 19–21F/18 cm Bio-Medicus arterial cannula. All venoarterial ECMO patients were catheterized with a 6F or 8F cannula for perfusion of the cannulated leg. Avalon Elite 31F (Maquet) was used for dual-lumen cannulation. The oxygenators were Hilite 7000LT (Medos Medizintechnik AG, Stolberg, Germany) or Quadrox (Maquet).

For anticoagulation, a bolus dose of unfractionated heparin was administered at cannulation followed by continuous infusion. Activated partial thrombin time was targeted between 1.5 and 2 times of normal. ECMO blood flow was maintained between 3.5 and 5.0 L/min to reach a preoxygenator oxygen saturation during venoarterial ECMO of greater than 65% (venovenous > 70%). Echocardiography was used to monitor cardiac function. Inopressors and/or inodilators were adjusted to maintain a mean arterial blood pressure (MAP) greater than 65 mm Hg.

All patients were treated with β-lactam antibiotics and vancomycin by continuous infusion. For monitoring of infection, cultures are performed twice weekly and when needed. Plasmapheresis is used on occasion as an adjunct with IV immunoglobulins. For ventilation, rest settings are applied where positive end-expiratory and driving pressures are reduced (20).

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Data Collection

Retrospective data were obtained from our local database (PasIva; Otimo Data AB, Kalmar, Sweden) and from patient charts. All adult patients admitted to our unit between January 2012 and December 2017 with septic shock were eligible for inclusion. Inclusion criteria were as follows: greater than 18 years old; septic shock (International Classification of Diseases, 10th Edition [ICD-10]: R65.1, R57.2) at acceptance for ECMO; fulfillment of the “Sepsis-3” definition (21); presence of cardiocirculatory failure requiring a support equivalent to a VIS greater than 50 (internal guidelines accessible on www.ecmo.se) to reach a target MAP greater than 65 mm Hg; and signs of organ hypoperfusion at the time of ECMO initiation. Patients not treated at our unit during the whole ECMO run and patients with ongoing cardiopulmonary resuscitation (CPR) at the time of ECMO initiation were excluded. However, patients who had received CPR and achieved return of spontaneous circulation prior to ECMO initiation were included. Data were coded and cannot be traced back to any certain individual. The study was approved by the Stockholm Regional Ethical Board.

Data were collected from the time of the first phone-call until discharge from the ECMO department or death. The following data were recorded: age, sex, body mass index, comorbidities, time for onset of sepsis, isolated pathogen/s, and focus of infection. At decision for ECMO, arterial blood gas, circulation, and ventilation parameters including echocardiography were recorded. At initiation of ECMO, Simplified Acute Physiology Score (SAPS-3) and Sequential Organ Failure Assessment Score (SOFA) were calculated. Doses of vasoactive agents, ECMO mode, and CPR during the last 24 hours were noted. The number of failing organs was evaluated as defined by SAPS-3. At arrival at our ECMO unit, cardiac function was assessed by echocardiography and the following laboratory samples recorded: WBC count, p-C-reactive protein, and p-procalcitonin. Antibiotic coverage was reevaluated, and patients were treated with at least one antibiotic active against the identified or suspected (empirical) pathogen. All adverse events during treatment were noted.

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Outcome Variables

Primary outcome variables were survival to discharge from ECMO unit, hospital survival, and survival at follow-up of at least 6 months. Secondary outcomes were days on ECMO and ECMO-associated complications.

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Statistical and Data Analysis

Data are presented as median (interquartile range [IQR]) unless the mean ± sd is given. For comparisons, Mann-Whitney U test for nonparametric data was performed. For categorical data, Fisher exact test was used. The standardized mortality ratio was calculated from the observed hospital mortality rate and the estimated mortality rate obtained from the median SAPS-3 score. Subsequently, the number needed to treat could be calculated. p value less than 0.05 was considered significant.

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RESULTS

One hundred forty-eight septic shock patients according to ICD-10 coding were identified. Thirty-seven were included in the study (Fig. 1). Patient characteristics are presented in Supplemental Digital Content 1 (http://links.lww.com/CCM/E601). Plasma procalcitonin was 86 μg/L (IQR, 49–236), p-C-reactive protein 249 mg/L (194–293), and WBC count 8.5 × 109/L (2.3–19.8). Positive blood cultures were obtained in 73% of the cases. In 54%, the primary site of infection was the lung (Table 1). Primary cultures showed Gram-negative (G–) infections in 12 patients and Gram-positive (G+) in 20 patients (Table 2). In one patient, both G+ and G– were found. The G– group had a higher requirement for epinephrine (p = 0.018) before ECMO, but the total amount of vasoactive support was similar. Otherwise, no differences were found (Table 2).

TABLE 1.

TABLE 1.

TABLE 2.

TABLE 2.

Figure 1.

Figure 1.

The median time from first contact to start of ECMO was 5 hours 45 minutes. Ten patients (37%) were commenced on venovenous and 27 on venoarterial ECMO. For further ECMO data, see Supplemental Digital Content 2 (http://links.lww.com/CCM/E602).

The Pao2-to-Fio2 ratio was 48.8 mm Hg (37.5–60 mm Hg) for venovenous and 60 mm Hg (50–74 mm Hg) for venoarterial (p < 0.03). Lactate was lower for the venovenous than for the venoarterial patients (3.65 mmol/L [3.3–7.0 mmol/L] vs 8.0 mmol/L [5.0–11 mmol/L]; p < 0.03). The ECMO flow was higher for venoarterial than for venovenous (4.6 L/min [4.3–5.1 L/min] vs 4.0 L/min [3.9–4.1 L/min]; p < 0.01), but the difference in effective ECMO blood flow was in reality higher because the recirculation fraction during venovenous-ECMO was not accounted for. There were no differences concerning MAP, heart rate, doses of norepinephrine and epinephrine, or VIS.

The subgroup of patients with left ventricular failure (LVF) at admission was supported with venoarterial rather than venovenous-ECMO (p < 0.05). The septic LVF patients had an ejection fraction of 25% (20–30) compared with 52.5% (40–60) for the non-LVF patients (p < 0.001). Hospital survival for the LVF patients was 90.0%, and long-term survival was 75.0%, in this group. The corresponding hospital survival for the non-LVF subjects was 64.7% (p = 0.044), and long-term survival was 47.1% (p = 0.081). In the whole sepsis cohort, survival from ECMO was 81.1%, hospital survival 78.4%, and at long-term follow-up (median, 46.1 mo), survival was 59.5% (Table 3). Five of the seven patients (71.4%) who experienced CPR before admission survived. Of the eight immunocompromised patients, one died during ECMO, the rest are still alive today (87.5%). Hospital survivors had a median SAPS-3 score of 85 (80.5–95) compared with 97 (87–100; p = 0.15) for the nonsurvivors. The deceased exhibited more organ failures than survivors, 6 (6–7) and 5 (4–6; p = 0.03), respectively. There was no difference in VIS and median SOFA score.

TABLE 3.

TABLE 3.

Commencement on venovenous-ECMO was associated with a higher risk for in-hospital death when compared with venoarterial (50% vs 11%; p = 0.011) and all-cause long-term mortality (70.0% vs 29.6%; p = 0.026), respectively. Long-term all-cause mortality was associated with more organ failures at admission (6 [5–6] vs 4.5 [4–6]; p = 0.036). However, there was no difference in the SAPS-3 score at admission, 85 (80–95) versus 87 (84–99), respectively, nor were there any differences concerning SOFA score, pH, lactate, Pao2/Fio2 doses of norepinephrine, epinephrine, or VIS.

Ventilator-associated pneumonia was reported in three of the eight registered complications (38%). Bleeding from cannulation site was seen in two patients, and two patients exhibited ischemia in the cannulated leg (venoarterial ECMO) which necessitated surgical care. All patients who expired during ECMO treatment were cases where ECMO treatment was withdrawn due to futility from intracranial events: major bleedings, ischemic events, or herniation (Supplemental Digital Content 2, http://links.lww.com/CCM/E602).

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DISCUSSION

We investigated 37 patients with septic shock during 6 consecutive years. These subjects were identified from the ICD-10 codes, fulfillment of Sepsis-3 criteria, and the need for a significant amount of vasoactive support. The cohort included two subsets of patients: septic shock with LVF (septic cardiomyopathy) and patients with distributive shock. LVF showed a higher survival. The number of organ failures at admissions affected both in-hospital and long-term survival.

Why ECMO reduce mortality is generally related to the increase of oxygen delivery as well as offering circulatory support (22). Failing circulation in the septic shock patient is caused by cardiac depression but also vasoplegia and capillary leakage causing displacement of intravascular volume exacerbating hypovolemia. This considered, it suggests that venoarterial ECMO supports the failing heart but will have less or no direct impact on the other parts causing hypotension, that is, vasoplegia and capillary leakage. However, secondary beneficial effects from improved tissue oxygenation may play a role in stabilizing the circulation. Even though ECMO treatment per se does not restore microcirculation or cellular/mitochondrial oxygen uptake, it could increase the chances thereof by augmenting oxygen delivery and secondary improvement of tissue perfusion in general: milieu intérieur. Therefore, we postulate that in distributive septic shock, venoarterial ECMO supports the circulation by limiting the negative impact of generalized poor oxygenation.

Lactic acidosis may be caused by factors other than anaerobic metabolism. It has been pointed out that hyperlactatemia may be seen before there is an imbalance between oxygen delivery and oxygen demand (2324). In septic shock, hypotension may exist with no or mildly elevated lactate. In the current study, 12 patients had a p-lactate greater than or equal to 9 mmol/L, the cutoff considered for when hyperlactatemia is driven by an anaerobic metabolism (2325). Thus, in these patients, ECMO may have helped alleviate the tissue oxygen deficiency by increasing oxygen delivery.

Of the 10 patients treated with venovenous-ECMO, hence not receiving any cardiac support, six patients still survived the septic shock episode. This could be pertained to the fact that venovenous-ECMO supplies oxygen. Venovenous-ECMO helps resuscitate a deficient oxygenation capability by the lung, but it will not support perfusion directly. However, it may do so by increased oxygenation in the coronaries leading to improved cardiac function.

In the few studies on patients with septic shock and ECMO treatment, the survival rates range from 15% to 71%. Two studies included ECPR patients making them hard to interpret (1011). In the study by Bréchot et al (8) on 14 septic shock patients with cardiac failure, 12 (86%) came off ECMO and survival after 13 months was 71%. Their results were comparable to the LVF subgroup in the current study. Their conclusion that ECMO was useful in patients with septic shock, and myocardial dysfunction is confirmed by our study. Vogel et al (26) reported 75% survival in patients with septic cardiomyopathy.

A retrospective study concerning patients treated at our institution between 1995 and 2013 found an overall survival of 64% (27). The same study showed that patients who survived the first 90 days after discharge had a 5-year survival rate of 87%. In the same material, there was no reduction of cognitive function among patients with prolonged hypoxemia (28).

Of the 17 patients in this study with distributive shock, 70.6% survived to discharge from hospital. Especially, venoarterial ECMO could be considered, not only for patients with myocardial dysfunction but also for distributive septic shock patients with preserved myocardial function. However, despite these findings, we believe that a randomized controlled trial with randomization between venoarterial ECMO and conventional intensive care should be performed before drawing any definite conclusions. Furthermore, our cohort of patients contained a mix of both venovenous and venoarterial ECMO patients. In retrospect, these patients may confuse the numbers especially because the majority of them later were converted to venoarterial ECMO. However, the current analysis was based on the initial ECMO mode which in its turn is based on the attending physicians’ experiences and context when selecting ECMO mode. Still conversion to venoarterial from venovenous was based on clinical assessment that venovenous-ECMO was not sufficient support for survival. Therefore, these patients were converted to venoarterial ECMO. These difficult decisions require both experience and thorough knowledge in treating this patient group. Another limitation of the study was the single high-volume center retrospective design making it difficult to draw general conclusions applicable to other ECMO practitioners. However, septic shock patients should only be treated at high-volume centers with experience and capability to perform all modes of ECMO (venovenous, venoarterial, and veno-venoarterial) according to patient’s need. These patients are complex to treat not only from an experience point of view but also concerning resource demand. Still no randomized control trials have been published on sepsis and ECMO. Although multicentric randomized studies are needed, these are difficult to conduct due to low numbers and treatment heterogeneity between centers (29). Larger well-designed prospective single-center studies would also add to our community’s knowledge.

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CONCLUSIONS

The results from this mixed population of both distributive septic shock and septic shock with cytotoxic cardiac failure with high risk for mortality indicate that peripheral cannulation ECMO support may be beneficial for both hospital and long-term survival. It cannot be emphasized enough that experience from septic shock patients is fundamental and that ECMO should be initiated by and/or at least continued at a high-volume ECMO center with experience in both venovenous and venoarterial ECMO for a dynamic approach to patient need. Further randomized controlled trials are warranted to investigate the effect of venoarterial ECMO in septic circulatory failure.

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Keywords:

cardiac failure; distributive; extracorporeal membrane oxygenation; septic shock; vasoplegia

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