50th Anniversary ArticlesClinical Research: From Case Reports to International Multicenter Clinical TrialsFinfer, Simon FRCP, FRCA, FCICM, FAHMS, DrMed1,2; Cook, Deborah MD3,4; Machado, Flavia R. MD, PhD5; Perner, Anders MD, PhD6Author Information 1 The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia. 2 School of Public Health, Imperial College, London, United Kingdom. 3 Department of Medicine, McMaster University, Hamilton, ON, Canada. 4 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. 5 Department of Anesthesiology, Pain and Intensive Care, Universidade Federal de São Paulo, São Paulo, Brazil. 6 Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal). The authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: [email protected] Critical Care Medicine: November 2021 - Volume 49 - Issue 11 - p 1866-1882 doi: 10.1097/CCM.0000000000005247 Buy SDC Metrics Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.