50th Anniversary ArticlesThe Multiple Organ Dysfunction Syndrome: Syndrome, Metaphor, and Unsolved Clinical ChallengeMarshall, John C. MD1; Deutschman, Clifford S. MD, MCCM2 Author Information 1 Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada. 2 Hofstra North Shore-LIJ School of Medicine, Feinstein Institute for Medical Research, Manhasset, NY. Dr. Marshall’s institution received funding from the Canadian Institutes of Health Research; he received funding from Society of Critical Care Medicine, AM Pharma, and Gilead Pharmaceuticals. Dr. Deutschman’s institution received funding from the National Institute of General Medical Sciences; he received funding from Society of Critical Care Medicine, Enlivex Inc, ICON Data Management, and Pfizer; he received support for article research from the National Institutes of Health. For information regarding this article, E-mail: [email protected] Critical Care Medicine 49(9):p 1402-1413, September 2021. | DOI: 10.1097/CCM.0000000000005139 Buy Metrics Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.