50th Anniversary ArticleSeverity of Illness and Predictive Models in Society of Critical Care Medicine’s First 50 Years: A Tale of Concord and ConflictKramer, Andrew A. PhD, FCCM1; Zimmerman, Jack E. MD, FCCM2; Knaus, William A. MD3Author Information 1 Prescient Healthcare Consulting, Charlottesville, VA. 2 The George Washington University School of Medicine, Washington, DC. 3 The University of Virginia, Charlottesville, VA. Dr. Kramer disclosed that he has a patent on technology mentioned in this article (SIGNIPHY), has had a consultancy with medical Decision Network, LLC, and he was the codeveloper of Acute Physiology and Chronic Health Evaluation (APACHE) IV, mortality probability model III, and OASIS. Dr. Zimmerman was codeveloper of APACHE II, APACHE III, and APACHE IV. Dr. Knaus was the inventor of APACHE, and codeveloped APACHE II and APACHE III. For information regarding this article, E-mail: [email protected] Critical Care Medicine: May 2021 - Volume 49 - Issue 5 - p 728-740 doi: 10.1097/CCM.0000000000004924 Buy Metrics Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.