1 Department of Anaesthesia and Intensive Care Policlinico San Martino IRCCS for Oncology and Neuroscience, Genova, Italy.
2 Department of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.
3 Department of Statistical Sciences, University of Padova, Padua, Italy.
4 Department and Laboratory of Intensive Care Medicine, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
5 Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands.
6 Neurointensive care unit, Department of Emergency and Urgency, San Gerardo Hospital, ASST- Monza, Monza, Italy.
The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigators are listed in the Appendix.
Dr. Robba participated in the conception of the work, data analysis and interpretation, article drafting, critical revision of the article, and final approval of the version to be published. Drs. Banzato, Iaquaniello, and Wiegers participated in data analysis and interpretation, article drafting, critical revision of the article, and final approval of the version to be published. Dr. Rebora participated and supervised in data analysis and interpretation, article drafting, critical revision of the article, and final approval of the version to be published. Dr. Huang involved in calculation of the serum creatinine (SCr) estimated using the modification of diet in renal disease (MDRD) method, critical revision of the article, and final approval of the version to be published. Dr. Meyfroidt involved in calculation of the SCr estimated using the MDRD method, participation in data interpretation, critical revision of the article, final approval of the version to be published. Dr. Citerio involved in conception of the work, supervision of the data collection, participation in data analysis and interpretation, drafting the article, critical revision of the article, and final approval of the version to be published. Dr. Citerio is guarantor of the entire article. The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury participants and investigators (nonauthor contributors) contributed to participation in the data collection.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).
Data used in the preparation of this article were obtained in the context of The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (registered at ClinicalTrials.gov NCT02210221), a large collaborative project, supported by the Framework 7 program of the European Union (602150). Supported, in part, by the Hannelore Kohl Stiftung (Germany), by OneMind (United States), and by Integra LifeSciences Corporation (United States).
Dr. Meyfroidt’s institution received funding from Research Foundation, Flanders, KULeuven Research Grant (C2), and Codman; he received funding from other consulting and advisory boards. Dr. Citerio is Editor-in-Chief of Intensive Care Medicine, and he reports grants, personal fees as Speakers’ Bureau Member and Advisory Board Member from Integra and Neuroptics; personal fees from Nestle and UCB Pharma, all outside of the submitted work. The remaining authors have disclosed that they do not have any potential conflicts of interest.
The Medical Ethics Committees of each participating center approved the CENTER-TBI study, and informed consent was obtained according to local regulations. The list of sites, Ethical Committees, approval numbers and approval dates can be found on the website: https://www.center-tbi.eu/project/ethical-approval.
The data supporting the findings in the study are available upon reasonable request from the senior author (G.C.) and are stored at https://center-tbi.incf.org/_5cf8e3d1c3b0d43708ebef42. Data used for the definition of the acute kidney injury stage are stored at https://center-tbi.incf.org/_5d1dc708f9753b41d06d7806 and at https://center-tbi.incf.org/_5db08eb0ec506a3052ee469c, respectively for what concerned the creatinine and the urine output values. Imaging data can be found at https://center-tbi.incf.org/_5cf4dbd0560bb01102b6b28e, data on vitals values at https://center-tbi.incf.org/_5cf4dce9560bb01102b6b28f, data regarding medications can be found at https://center-tbi.incf.org/_5cf4de0d560bb01102b6b291, whereas daily therapy intensity level data are stored at https://center-tbi.incf.org/_5d302771462c403213f35e35.
For information regarding this article, E-mail: [email protected]
