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Features of Adult Hyperammonemia Not Due to Liver Failure in the ICU

Sakusic, Amra MD1–3; Sabov, Moldovan MD3; McCambridge, Amanda J. MD4; Rabinstein, Alejandro A. MD5; Singh, Tarun D. MBBS5; Mukesh, Kumar MD6; Kashani, Kianoush B. MD, MS7; Cook, David MBBS, PhD8; Gajic, Ognjen MD, MSc3,4

doi: 10.1097/CCM.0000000000003278
Online Clinical Investigations
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Objectives: To evaluate the epidemiology of hyperammonemia unrelated to liver failure in the critical care setting.

Design: Retrospective case series.

Setting: Critically ill patients admitted to ICUs at Mayo Clinic, Rochester, MN (medical ICU, two mixed medical-surgical ICUs, coronary care unit, or the cardiosurgical ICU) between July 1, 2004, and October 31, 2015.

Patients: Adult critically ill patients with hyperammonemia not related to acute or chronic liver failure. We excluded patients with diagnosis of moderate or severe liver disease, hyperbilirubinemia, and patients who denied the use of their medical records.

Interventions: None.

Measurements and Main Results: Of 3,908 ICU patients with hyperammonemia, 167 (4.5%) had no evidence of acute or chronic liver failure. One-hundred one patients (60.5%) were male with median age of 65.7 years (interquartile range, 50–74.5 yr) and median serum ammonia level of 68 µg/dL (interquartile range, 58–87 µg/dL). Acute encephalopathy was present in 119 patients (71%). Predisposing conditions included malnutrition 27 (16%), gastric bypass six (3.6%), total parenteral nutrition four (2.4%); exposure to valproic acid 17 (10%); status epilepticus 11 (6.6%), high tumour burden 19 (11.3%), and renal failure 82 (49.1%). Urea cycle defects were diagnosed in seven patients (4.1%). Hospital mortality was high (30%), and median ammonia level was higher among the nonsurvivors (74 vs 67 µg/dL; p = 0.05). Deaths were more likely in hyperammonemic patients who were older (p = 0.016), had greater illness severity (higher Acute Physiology and Chronic Health Evaluation III score, p < 0.01), malignancy (p < 0.01), and solid organ transplantation (p = 0.04), whereas seizure disorder was more common in survivors (p = 0.02). After adjustment, serum ammonia level was not associated with increased mortality.

Conclusions: Hyperammonemia occurs in a substantial minority of critically ill patients without liver failure. These patients have a poor prognosis, although ammonia level per se is not independently associated with mortality. Serum ammonia should be measured when risk factors are present, such as nutritional deficiencies and protein refeeding, treatment with valproic acid, high tumour burden, and known or suspected urea cycle abnormalities.

1Departments of Internal Medicine and Pulmonary Medicine, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.

2University of Tuzla, Medical Faculty, Tuzla, Bosnia and Herzegovina.

3Multidisciplinary Epidemiology and Translational Research in Intensive Care, Emergency and Perioperative Medicine (METRIC), Mayo Clinic, Rochester, MN.

4Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.

5Department of Neurology, Mayo Clinic, Rochester, MN.

6Montefiore Medical Center, North Division (Wakefield), New York, NY.

7Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.

8Intensive Care Unit, Princess Alexandra Hospital, Brisbane, QLD, Australia.

Drs. Sakusic and Gajic take full responsibility for the data, the analysis and interpretation, and the conduct of research. Drs. Sabov, McCambridge, Rabinstein, Mukesh, Kashani, and Cook have made substantial contribution to conception and design, acquisition of data, analysis, and interpretation. All the authors have provided the final approval of the version to be published.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).

Supported in part, by funding from The Mayo Critical Care Research Committee and grants from the National Institute on Aging (U01 AG006786, P50 AG016574 and R01 AG034676).

Dr. Gajic’s institution received funding from the Mayo Critical Care Research Committee and the National Institute on Aging (U01 AG006786, P50 AG016574 and R01 AG034676). The remaining authors have disclosed that they do not have any potential conflicts of interest.

For information regarding this article, E-mail: Gajic.Ognjen@mayo.edu

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