From the Department of Surgery (TPC, JL, JPC), Cellular Injury and Adaptation Laboratory, Burn, Trauma, and Surgical Critical Care Section, and the Department of Surgery and Division of Biostatistics (MP), Washington University School of Medicine, St. Louis, MO.

The final arbiter of the success of any scientific result, whether derived from a systematic, broad-scale approach or a more focused investigation, is the reproducibility of the finding.

Supported, in part, by grants from the National Institute of General Medical Sciences (GM59960 and GM59960–02S1) and The American College of Surgeons George H. A. Clowes Jr Memorial Research Career Development Award (to JPC).

Address requests for reprint to: J. Perren Cobb, MD, Department of Surgery, Campus Box 8109, 660 S. Euclid Ave., St. Louis, MO 63110-1093. E-mail: cobb@msnotes.wustl.edu