1 Adult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.
2 William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
3 Department of Critical Care Medicine, Queen’s University, Kingston, ON, Canada.
4 Clinical Evaluation Research Unit, Kingston Health Science Center, Kingston, ON, Canada.
5 Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.
*See also p. 1156.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).
Drs. Prowle and Puthucheary are joint senior authors.
Drs. Haines, Prowle, and Puthucheary conceptualized and designed the study, interpreted data, and wrote the first draft of the article. Drs. Haines, Prowle, and Puthucheary developed the initial approach to the study. Drs. Heyland and Day provided access to the database and reviewed the statistical analysis plan. Drs. Haines, Fowler, Wan, and Flower performed data collection and cleaning. Drs. Haines and Prowle did analyses. Drs. Haines and Prowle produced the figures. Dr. Prowle had full access to all the data in the study and had final responsibility for the decision to submit for publication. All authors critically revised the final article.
Dr. Pearse’s institution received funding from Intersurgical and Edwards Lifesciences; he received funding from GlaxoSmithKline. Dr. Prowle received funding from Fresenius Kabi, Baxter, Nikkiso Europe GmbH Consultancy, Jafron Biomedical, Mission Therapeutics, Quark Pharma, Medibeacon, and Biomerieux. Dr. Puthucheary received funding from Nestle, Fresenius Kabi, Nutricia, Faraday Pharmaceuticals, and Baxter. The remaining authors have disclosed that they do not have any potential conflicts of interest.
Anonymized clinical data are available upon request, subject to an internal review by Drs. Heyland and Day with completion of a data sharing agreement.
The R code used to generate all results of this article is available upon request. Requests will be subject to internal review by Drs. Haines and Prowle. Code for directed acyclic graphs are provided in the Supplement (https://links.lww.com/CCM/H24).
For information regarding this article, E-mail: [email protected]
