50th Anniversary ArticlesCardiopulmonary Resuscitation and Rescue TherapiesDalton, Heidi J. MD, MCCM, FELSO1; Berg, Robert A. MD, MCCM2; Nadkarni, Vinay M. MD, MS, FCCM2; Kochanek, Patrick M. MD, MCCM3; Tisherman, Samuel A. MD4; Thiagarajan, Ravi MBBS, MPH5; Alexander, Peta MBBS5; Bartlett, Robert H. MD, FELSO6Author Information 1 Heart and Vascular Institute and Department of Pediatrics, INOVA Fairfax Medical Center, Falls Church, VA. 2 Department of Critical Care, Children’s Hospital of Philadelphia, Philadelphia, PA. 3 Department of Anesthesiology/Critical Care Medicine, Peter Safer Resuscitation Center, Pittsburgh, PA. 4 Department of Surgery, R Adams Cowley Shock Trauma Center, Baltimore, MD. 5 Department of Cardiology, Division of Cardiovascular Critical Care, Boston Children’s Hospital, Boston, MA. 6 Department of Surgery, University of Michigan, Ann Arbor, MI. Dr. Dalton received funding from Innovative ECMO Concepts, Inc; she disclosed the off-label product use of new resuscitative tools and monitoring equipment. Dr. Tisherman disclosed that he is the coauthor of a patent for “Emergency Preservation and Resuscitation Method”; he disclosed the off-label product use of normal saline and cardiopulmonary bypass equipment; he is supported by U.S. Army Medical Acquisition Activity (W81XWH1810601). Dr. Thiagarajan’s institution received funding from Bristol Myers Squibb and Pfizer; he received funding from Advocate Children’s Hospital. Dr. Alexander’s institution received funding from Novartis; she received finding from Instrumentation Laboratories; she disclosed the off-label product use of extracorporeal membrane oxygenation under extracorporeal cardiopulmonary resuscitation conditions. Dr. Kochanek received funding from Pediatric Critical Care Medicine for serving as the Editor-in-Chief, the National Institutes of Health, and the U.S. Army; he disclosed he is a patent holder for the United States Invention Disclosure, “Method to improve neurologic outcomes in temperature managed patients” (No. 62/164,205), the United States Invention Disclosure, “Small Molecule Inhibitors of RNA Binding MOTIF Proteins for the Treatment of Acute Cellular Injury” and the United States Patent 8,628,512 B2, “Method of Inducing EPR Following Cardiopulmonary Arrest”. Dr. Kochanek is supported by NS105721 from the National Institutes of Neurologic Disorders and Stroke/the National Institutes of Health, and the American Heart Association (18TPA34170553). The remaining authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: [email protected] Critical Care Medicine: September 2021 - Volume 49 - Issue 9 - p 1375-1388 doi: 10.1097/CCM.0000000000005106 Buy Metrics Abstract The history of cardiopulmonary resuscitation and the Society of Critical Care Medicine have much in common, as many of the founders of the Society of Critical Care Medicine focused on understanding and improving outcomes from cardiac arrest. We review the history, the current, and future state of cardiopulmonary resuscitation. Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.