1 Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2 Julius Wolff Institut for Biomechanics and Musculoskeletal Regeneration, Charité-Universitätsmedizin Berlin, Berlin, Germany.
3 University Center of Orthopaedics and Traumatology, University Hospital Dresden, Dresden, Germany.
4 Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, Hamburg, Germany.
5 Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
6 Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
7 Department of Traumatology, Center of Surgery, University of Ulm, Ulm, Germany.
8 Center for Musculoskeletal Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.
9 Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
10 Berlin Institute of Health (BIH), Berlin, Germany.
Drs. Baranowsky and Appelt contributed equally.
Drs. Baranowsky, Appelt, Lange, and Jahn, Ms. Pandey, Ms. Keller, Dr. Schetler, Ms. Braumüller, and Dr. Yorgan performed and analyzed most of the in vivo and in vitro experiments. Dr. Ludewig performed and analyzed flow cytometry. Drs. Kleber, Rose, and Tsitsilonis contributed clinical data and human samples. Ms. Braumüller and Dr. Huber-Lang assisted with cecal ligation and puncture model and corrected the manuscript. Drs. Frosch, Amling, Schinke, and Keller supervised the study and critically reviewed the manuscript. Drs. Baranowsky, Appelt, and Keller wrote the manuscript. All authors reviewed and approved the final version of the submitted manuscript.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).
Supported, in part, by grants from the Deutsche Forschungsgemeinschaft (DFG) given to Dr. Amling (AM103/24-1) and Dr. Keller (DFG KE 2179/4-1), and by grants from the Berlin Institute of Health given to Dr. Keller.
Drs. Amling and Keller are named inventors of a patent application related to the work described. Dr. Keller disclosed off-label product use of olcegepant (BIBN-4096; BIBN 4096BS). Dr. Baranowsky disclosed government work. Dr. Frosch disclosed that he and his institution received funding from Arthrex. The remaining authors have disclosed that they do not have any potential conflicts of interest.
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