To examine the proportion and rate of central venous access device failure and complications across central venous access device types in adult intensive care.
A systematic search was undertaken in the electronic databases Cochrane Central Register of Controlled Trials, Embase, U.S. National Library of Medicine National Institutes of Health, and Cumulative Index to Nursing and Allied Health in September 2017.
Included studies were of observational (prospective and retrospective) or interventional design and reported central venous access device failure and complications in adult ICU settings. Studies were excluded if they were published prior to November 2006 or not reported in English. Two reviewers independently screened articles, assessed eligibility, extracted data, and assessed risk of bias.
Data were extracted on the primary outcome, central venous access device failure, and secondary outcomes: central venous access device complications (central line-associated bloodstream infection, catheter-related bloodstream infection, catheter-related thrombosis, occlusion, catheter removal due to suspected infection, dislodgement, breakage, and local infection). Patient and device data and study details to assess the study quality were also extracted.
A total of 63 studies involving 50,000 central venous access devices (396,951 catheter days) were included. Central venous access device failure was 5% (95% CI, 3–6%), with the highest rates and proportion of failure in hemodialysis catheters. Overall central line-associated bloodstream infection rate was 4.59 per 1,000 catheter days (95% CI, 2.31–6.86), with the highest rate in nontunneled central venous access devices. Removal of central venous access device due to suspected infection was high (17%; 20.4 per 1,000 catheter days; 95% CI, 15.7–25.2).
Central venous access device complications and device failure is a prevalent and significant problem in the adult ICU, leading to substantial patient harm and increased healthcare costs. The high proportion of central venous access devices removed due to suspicion of infection, despite low overall central line-associated bloodstream infection and catheter-related bloodstream infection rates, indicates a need for robust practice guidelines to inform decision-making surrounding removal of central venous access devices suspected of infection.
1Alliance for Vascular Access Teaching and Research (AVATAR) group, Menzies Health Institute Queensland, Griffith University, Nathan, QLD, Australia.
2Department of Anaesthesia and Pain Management, Lady Cilento Children’s Hospital, South Brisbane, QLD, Australia.
3School of Nursing and Midwifery, Nathan Campus, Griffith University, Nathan, QLD, Australia.
4Centre for Applied Health Economics, Menzies Health Institute Queensland, Nathan Campus, Nathan, QLD, Australia.
5School of Medicine, Griffith University, Nathan, QLD, Australia.
*See also p. 2054.
This work was performed at Alliance for Vascular Access Teaching and Research (AVATAR) group, Menzies Health Institute Queensland, Griffith University, Nathan, QLD 4111, Australia.
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Supported, in part, by the institutional departmental funds.
Dr. Ullman, through her employer (Griffith University), has received investigator-initiated, unrestricted research grants from vascular access manufacturers (3M, Adhezion, Angiodynamics, Becton Dickinson, Centurion Medical Products [Medline]), independent from this study. The remaining authors have disclosed that they do not have any potential conflicts of interest.
Address requests for reprints to: Mari Takashima, RN, BN, Grad Cert ICU, MEpi, Alliance for Vascular Access Teaching and Research (AVATAR) group, Menzies Health Institute Queensland, Griffith University, Nathan, QLD 4111, Australia. E-mail: firstname.lastname@example.org