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Iodide Improves Outcome After Acute Myocardial Infarction in Rats and Pigs

Morrison, Michael L., PhD1; Iwata, Akiko, PhD1; Keyes, Christopher C., BS1; Langston, Will, PhD2; Insko, Michael A., BS2; Langdale, Lorrie A., MD3; Roth, Mark B., PhD1

doi: 10.1097/CCM.0000000000003353
Online Laboratory Investigation

Objectives: In this study, we tested whether iodide would reduce heart damage in rat and pig models of acute myocardial infarction as a risk analysis for a human trial.

Design: Prospective blinded and randomized laboratory animal investigation.

Setting: Animal research laboratories.

Subjects: Sexually mature rats and pigs.

Interventions: Acute myocardial infarction was induced by temporary ligation of the coronary artery followed by reperfusion. Iodide was administered orally in rats or IV in rats and pigs just prior to reperfusion.

Measurements and Main Results: Damage was assessed by blood cardiac troponin and infarct size; heart function was determined by echocardiography. Blood peroxide scavenging activity was measured enzymatically, and blood thyroid hormone was determined using radioimmune assay. Iodide administration preserved heart function and reduced blood cardiac troponin and infarct size by approximately 45% in pigs and approximately 60% in rats. Iodide administration also increased blood peroxide scavenging activity and maintained thyroid hormone levels.

Conclusions: Iodide administration improved the structure and function of the heart after acute myocardial infarction in rats and pigs.

1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

2Faraday Pharmaceuticals, Seattle, WA.

3Department of Surgery, Veterans Administration-Puget Sound Health Care System, Seattle Division and University of Washington, Seattle, WA.

Supported both by an Army Research Office grant to Dr. Roth for pig experiments performed at Fred Hutchinson Cancer Research Center and Puget Sound Veterans Administration and by Faraday Pharmaceuticals for rat experiments performed at Faraday Pharmaceuticals.

Drs. Morrison’s and Iwata’s, Mr. Keyes’, and Dr. Roth’s institution received funding from Army Research Offices and Faraday Pharmaceuticals. Drs. Morrison, Iwata and Roth are named inventors on patents licensed to Faraday Pharmaceuticals; they received funding from Faraday Pharmaceuticals (royalties and shares). Dr. Langston and Mr. Insko are employees of Faraday Pharmaceuticals. Dr. Langdale’s institution received funding from the Department of Defense (DoD); she received support for article research from the DoD; and she disclosed government work.

For information regarding this article, E-mail: mroth@fredhutch.org

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