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Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study*

Shehabi, Yahya PhD, FCICM, FANZCA, EMBA1,2; Bellomo, Rinaldo MD (Hons), FRACP, FCICM3,4,5; Kadiman, Suhaini MD, M.MED6; Ti, Lian Kah MBBS, Mmed7; Howe, Belinda RN, BN8; Reade, Michael C. MBBS, MPH, Dphil, FCICM9; Khoo, Tien Meng MBBS, MRCP, EDIC10; Alias, Anita MD, MMed(Anaesth)11; Wong, Yu-Lin FANZCA, MMed (ICM)12; Mukhopadhyay, Amartya FRCP, MPH7; McArthur, Colin MBChB, FANZCA, FCICM13; Seppelt, Ian MBBS, BSc (Med), FANZCA, FCICM14; Webb, Steven A. MPH, PhD, FCICM8,15; Green, Maja PhD, MSc, BSc (Hons)1; Bailey, Michael J. PhD, MSc (statistics), BSc (Hons)1,8; for the Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group

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doi: 10.1097/CCM.0000000000003071
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