1CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
2Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
3Intensive Care Unit, Hospital General de Ciudad Real, Ciudad Real, Spain.
4Intensive Care Unit, Complejo Asistencial Universitario de León, León, Spain.
5Intensive Care Unit, Hospital Universitario Río Hortega, Valladolid, Spain.
6Department of Anesthesiology, Hospital Clínico Universitario, Valencia, Spain.
7Intensive Care Unit, Hospital Universitario Morales Meseguer, Murcia, Spain.
8Intensive Care Unit, Hospital Universitario A Coruña, Coruña, Spain.
9Intensive Care Unit, Hospital Virgen de La Luz, Cuenca, Spain.
10Intensive Care Unit, Hospital Clínico Universitario, Valladolid, Spain.
11Intensive Care Unit, Hospital Universitario La Paz, Madrid, Spain.
12Intensive Care Unit, Hospital Universitario Virgen de Arrixaca, Murcia, Spain.
13Intensive Care Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain.
14Department of Surgical Sciences, Anesthesiology & Critical Care, Hedenstierna Laboratory, Uppsala University Hospital, Uppsala, Sweden.
15Intensive Care Unit, Hospital Virgen de la Concha, Zamora, Spain.
16Intensive Care Unit, Hospital Universitario Carlos Haya, Málaga, Spain.
17Critical Care Center, Corporació Sanitaria Parc Taulí, Sabadell, Spain.
18Research Unit, Hospital Universitario NS de Candelaria, Santa Cruz de Tenerife, Spain.
19Department of Respiratory Care, Massachusetts General Hospital, Boston, MA.
20Department of Anesthesia, Harvard University, Boston, MA.
*See also p. 919.
This study is registered with www.clinicaltrials.gov (NCT00435110, NCT00736892, NCT02288949).
Additional investigators from the Spanish Initiative for Epidemiology, Stratification and Therapies of ARDS (SIESTA) Network are listed in Appendix 1.
Drs. Villar and Kacmarek designed the original study. Drs. Martín-Rodríguez, Domínguez-Berrot, Fernández, Ferrando, Soler, Díaz-Lamas, González-Higueras, Nogales, Ambrós, Carriedo, Hernández, Martínez, Blanco, Belda, Parrilla, Suárez-Sipmann, Tarancón, Mora-Ordoñez, and Blanch enrolled patients and collected the data. Dr. Villar obtained funding for the study. Drs. Villar, Martín-Rodríguez, Domínguez-Berrot, Fernández, Ferrando, Soler, Díaz-Lamas, González-Higueras, Nogales, Ambrós, Carriedo, Hernández, Martínez, Blanco, Belda, Parrilla, Suárez-Sipmann, Tarancón, Mora-Ordoñez, Blanch, Pérez-Méndez, Fernández, and Kacmarek made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data; drafting the article or revising it critically for important intellectual content; and approved the final version to be published. Drs. Villar, Blanco, Belda, Suárez-Sipmann, Pérez-Méndez, Fernández, and Kacmarek wrote the first draft. Drs. Villar, Fernández, Pérez-Méndez, and Kacmarek performed and supervised data management and statistical analysis. Drs. Villar, Fernández, and Pérez-Méndez had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).
Supported, in part, by Instituto de Salud Carlos III (CB06/06/1088, PI10/0393, PI13/0119), Fundación Mutua Madrileña (AP101822012), and Asociación Científica Pulmón y Ventilación Mecánica.
Dr. Villar received funding from a research grant from Maquet. Dr. Suárez-Sipmann received funding from Maquet Critical Care (consulting services). Dr. Kacmarek received funding from Covidien (consulting on airway care), Orange Medical (consultant on Mechanical Ventilation), Teleflex (consultant on humidification); he disclosed a grant from Venner Medical on airway care, funding from lecturing for Teleflex, and for the 2016 AARC meeting industry sponsored session sponsored by Covidien. The remaining authors have disclosed that they do not have any potential conflicts of interest.
For information regarding this article, E-mail: [email protected]