1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN.
2Division of Anesthesiology Critical Care Medicine, Vanderbilt University, Nashville, TN.
3Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA.
4Division of Critical Care, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
5Institute for Software Integrated Systems, Vanderbilt University School of Engineering, Nashville, TN.
6Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN.
7Department of Internal Medicine, Meharry Medical College, Nashville, TN.
*See also p. 1776.
This work was performed at Vanderbilt University Medical Center, Nashville, TN.
Dr. Semler had full access to all the data and had final responsibility for the decision to submit for publication. Drs. Semler, Weavind, Hooper, Rice, Martin, Bernard, and Wheeler contributed to study concept and design. Dr. Semler, Dr. Weavind, Dr. Hooper, Ms. Gowda, Mr. Nadas, and Dr. Wheeler contributed to acquisition of the data. Dr. Semler, Dr. Weavind, Dr. Rice, Ms. Gowda, Mr. Nadas, Ms. Song, Dr. Bernard, and Dr. Wheeler contributed to data analysis and interpretation. Drs. Semler, Weavind, Rice, and Wheeler contributed to article preparation and drafting. Dr. Semler, Dr. Weavind, Dr. Rice, Ms. Gowda, and Ms. Song contributed to statistical methods and statistical data analysis. All authors contributed to article critique and review. All authors approved the submitted article.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (http://journals.lww.com/ccmjournal).
All authors received support for article research from the National Institutes of Health (NIH) (1RC1LM010310-01), National Center for Research Resources (NCRR)/NIH (1 UL1 RR024975), and National Science Foundation (NSF) (CCF-0424422). Their institutions received grant support from the NIH (1RC1LM010310-01), NCRR/NIH (1 UL1 RR024975), and NSF (CCF-0424422). Dr. Hooper consulted for Biomereux. Dr. Rice consulted for Avisa Pharma (Advisory Board) and GlaxoSmithKline (Data and Safety Monitoring Board Member). Dr. Wheeler consulted for Cumberland Pharmaceuticals; lectured for numerous grand round presentations at academic institutions; received royalties for a textbook; has stock in Cumberland Pharmaceuticals; and received grant support (investigator on numerous NIH grants not related to this project). The funding sources were not involved in the design, data collection, analysis, interpretation, or reporting of the study. All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest.
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