1Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium.
2Department of Surgery, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.
3Department of Medicine, Monash University, Monash Medical Center, Clayton, Victoria, Australia.
4Division of Infectious Disease, Beverly Hospital/Lahey Health, Beverly, MA.
5Department of Anesthesiology and Critical Care Medicine, Charles University Prague and Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic.
6Department of Emergency & Critical Care Medicine, School of Medicine, Keio University, Shinjukuku, Tokyo, Japan.
7Department of Intensive Care Medicine, Ghent University Hospital, Ghent University, Research Foundation-Flanders, Ghent, Belgium.
8Howard Levy Consulting LLC, Hopewell, NJ.
9Pacific Northwest Statistical Consulting, Woodinville, WA.
10Department of Vascular Medicine and Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands.
11Department of Medicine, Maulana Azad Medical College, New Delhi, India.
12Division of Critical Care Medicine, Faculty of Medicine and Dentistry, The University of Alberta, Royal Alexandra Hospital, Edmonton, Alberta, Canada.
13Department of Medicine, McMaster University and St Joseph’s Hospital, Hamilton, Canada.
14Department of Medicine, Vanderbilt University, Nashville, TN.
15Department of Intensive Care, CHU Brugmann, Brussels, Belgium.
16Servei d’urgències, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
17Department of Intensive Care, Hospital San Martín, Paraná, Argentina.
18Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, Oklahoma City, OK.
19Chairman, Heart and Vascular Hospital, Hackensack University Medical Center; Professor of Medicine, New Jersey Medical School of Rutgers University, Hackensack, NJ.
20Florida Hospital, Orlando, FL.
21Department of Intensive Care, Christchurch Hospital, Christchurch, New Zealand.
22Division of Pulmonary and Critical Care, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
23Mehta Hospital & Cardiopulmonary Care Centre, Ahmedabad, India.
24Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL.
25Metro Hospitals, Noida, India.
26Asahi Kasei Pharma America Corporation, Waltham, MA.
27Zymo Consulting Group LLC, Newtown Square, PA.
* See also p. 2221.
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Supported, in part, by Asahi-Kasei Pharma America Corporation.
Dr. Vincent was a member of the ART-123 advisory committee, was compensated for his time as a consultant for Artisan Pharma, and received grant support from Artisan Pharma. Dr. LaRosa has received consulting honoraria from Artisan Pharma, ExThera Medical, and Agennix AG. Dr. Aikawa received consultation fees from Asahi-Kasei for the Japanese P-3 and P-4 studies and expenses from Artisan Pharma for attending PAB meeting in July 17, 2009. Dr. Levy is a paid consultant for Artisan Pharma. Dr. Hirman is a paid consultant for Asahi-Kasei Pharma America. Dr. Levi was a member of the ART-123 advisory committee and was compensated for his time as a consultant for Artisan Pharma. Dr. Crowther discloses having sat on advisory boards for Leo Pharma, Pfizer, Bayer, Boehringer Ingelheim, Alexion, CSL Behring, Portola, Viropharm, and AKP America; has prepared educational materials for Pfizer, Octapharm, and CSL Behring; holds a Career Investigator award from the Heart and Stroke Foundation of Ontario, and the Leo Pharma Chair in Thromboembolism Research at McMaster University; and has received funding for presentations from Leo Pharma, Bayer, Celgene, and CSL Behring. Dr. Bernard was a member of the ART-123 advisory committee and was compensated for his time as a consultant for Artisan Pharma. Dr. Esmon serves as a consultant for Portola Pharmaceuticals, Bayer HealthCare Pharmaceuticals, and Asahi Kasei Pharma America Corporation. He holds a patent for monoclonal antibodies against activated protein C and has a patent pending on histones for therapeutic use and biomarkers for prognosis. Dr. Parrillo was a member of the ART-123 advisory committee and was compensated for his time as a consultant for Artisan Pharma. Dr. Guzzi has received honoraria as a speaker for GlaxoSmithKline, Hospira, and EKR Therapeutics. Dr. Fareed is a consultant to Polymedix, Mitsubishi, Asahi-Kasei and Gentium, has received grant support from Sanofi-Aventis, Medefil and honoraria from Pharmaceutical Strategic Initiatives. Dr. Tsuruta owned stocks of Asahi Kasei Corporation which is the holding company of Asahi Kasei Group, study sponsors. Dr. Gorelick is a paid consultant to ArtisanPharma and an option holder in Artisan Pharma. He is a consultant to NGN Capital, which held stock in Artisan Pharma. He is a consultant to Asahi Kasei Pharma America. Mr. Osawa is an employee of Artisan Pharma, a former body of Asahi Kasei Pharma America Corporation but has no equity in the company. Dr. Kaul was an employee of Artisan Pharma, who sponsored this study and was offered company stock options. Artisan Pharma was bought out by Asahi Kasei Pharma and the surviving entity became Asahi Kasei Pharma America. He has no equity position in this new company but remains an employee. The remaining authors have disclosed that they do not have any potential conflicts of interest.
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