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Clinical Investigations

Pancreatic Stone Protein Predicts Outcome in Patients With Peritonitis in the ICU*

Gukasjan, Raphael MD1; Raptis, Dimitri Aristotle MD MSc2; Schulz, Hans-Ulrich MD1; Halangk, Walter PhD1; Graf, Rolf PhD2

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doi: 10.1097/CCM.0b013e3182771193



In the article in the April 2013 issue, starting on page 1027, several of the SDC links incorrectly link to past Supplemental Digital Content.

On page 1030, the following paragraphs are updated:

Association of Blood Parameters With Clinical Conditions and Outcomes

Table 2 demonstrates the association of WBC, CRP, IL-6, PCT, and PSP with different clinical conditions, such as the severity and localization of peritonitis, the presence of organ failure, and mortality in the ICU. PSP was the only blood parameter that significantly differed among all clinical conditions and nearly all of their subgroups on univariate analysis (Table 2, Figs. 1–2; Table S3 and Fig. S5, Supplemental Digital Content 1, ). Furthermore, PSP and PCT were the only blood parameters with a predictive value for the need for renal replacement in the ICU (Fig. S2, Supplemental Digital Content 1, ).

Blood Parameter and Clinical Score Correlation

PSP best correlated with the clinical scores (MPI, APACHE II, and SOFA scores) when compared with WBC, CRP, IL-6, and PCT (Table S1 and Fig. S4, Supplemental Digital Content 1, ). Similarly, PSP was the only blood parameter that significantly differed among the clinical scores when grouped according the cut-off points generated by the ROC curves (Table S2 and Fig. S3, Supplemental Digital Content 1, ).

The fourth and sixth paragraph of the Blood Parameters and Clinical Score Prediction of Death in the ICU section on pages 1031 and 1032, respectively, should be:

Similarly, we assessed the clinical scores in predicting death in the ICU using ROC curve analysis. The SOFA score was superior to APACHE II or MPI score in predicting death in the ICU (Fig. S1, Supplemental Digital Content 1, ). Figure 4 further illustrates the 90-day survival of patients with a PSP < 130 vs. ≥ 130, being 96% and 74%, respectively (Cox regression hazard risk ratio: 6.48 [95% confidence interval, 1.45–28.97]; p = 0.015).

To further substantiate the potential of PSP as a predictive factor, we performed a multivariate stepwise regression analysis. Among all available blood parameters, PSP was the only independent predicting factor for death in the ICU (Table 4). Similarly, among the clinical scores, SOFA and APACHE II were independent predictive factors for death in the ICU (Table S4, Supplemental Digital Content 1, ).

Critical Care Medicine. 41(6):e104, June 2013.

© 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins