1 Sunnybrook Research Institute, Sunnybrook Health Sciences Center and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
2 Department of Medicine, Kingston General Hospital, Queen’s University, Kingston, Ontario, Canada
3 Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
4 Department of Medicine, Center for Health Evaluation and Outcome Sciences, Providence Health Care and University of British Columbia, Vancouver, British Columbia, Canada.
5 Department of Critical Care, Thunder Bay Health Sciences Center, Thunder Bay, Ontario, Canada.
6 Department of Critical Care, Fraser Health Authority, British Columbia, Canada.
7 Division of Critical Care, Department of Medicine, University of British Columbia, British Columbia, Canada.
8 Royal Columbian Hospital, New Westminster, British Columbia, Canada.
9 Vancouver Island Health Authority, Victoria, British Columbia, Canada.
10 Department of Medicine, Section of Critical Care, Hotel-Dieu Grace Hospital, Windsor, Ontario, Canada.
11 Department of Internal Medicine, Central Michigan University, Mount Pleasant, MI.
12 Geisinger Medical Center, Danville, PA.
13 Department of Medicine, William Osler Health Center, Toronto, Ontario, Canada.
14 Department of Critical Care, The Ottawa Hospital and Division of Critical Care, University of Ottawa, Ottawa, Ontario, Canada.
*See also p. 329.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (http://journals.lww.com/ccmjournal).
Peer-review funding for the study was received from the Canadian Institutes of Health Research (CIHR). Supplementary funding was also received from Astra-Zeneca, Bayer, and Covidien through unrestricted study grants. None of the funders had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the article. Dr. Sinuff was supported by a CIHR Clinician Scientist Award during the conduct of this study. Dr. Cook holds a CIHR Research Chair.
Dr. Sinuff, Ms. Jiang, and Mr. Day had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Currently listed as ClinicalTrials.gov NCT 00434460.
The authors have not disclosed any potential conflicts of interest.
For information regarding this article, E-mail: taz.sinuff@sunnybrook.ca
