From the Department of Medicine (CSC, MAM), Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA; Cardiovascular Research Institute (CSC, JA, MAM), San Francisco, CA; Department of Anesthesia (CSC, MAM), University of California San Francisco, San Francisco, CA; Department of Medicine (DG), Division of Pulmonary, Critical Care and Sleep, Beth Israel Deaconess Medical Center Boston, MA; Department of Medicine (BTT), Pulmonary and Critical Care Medicine Unit, Massachusetts General Hospital, Boston, MA; Biostatistics Unit (BTT), Massachusetts General Hospital, Boston, MA.
*See also p. 1966.
Supported, in part, by contracts (NO1-HR 46046-64 and NO1-HR-16146-54) with the National Heart, Lung, and Blood Institute (NHLBI). Dr. Calfee was supported by HL090833, by the Flight Attendant Medical Research Institute, and by KL2RR024130 from the NCRR, a component of the NIH. Dr. Matthay was supported by HL 51856.
Drs. Calfee and Gallagher contributed equally to this work.
Dr. Calfee consulted for GlaxoSmithKline and Ikaria. D. Gallagher has worked at Merck Research Labs in December 2010 (after all the work on the manuscript was complete). The remaining authors have not disclosed any potential conflicts of interest.
The following persons and institutions participated in the FACTT trial:
Steering Committee Chair: G.R. Bernard; Clinical Coordinating Center: D.A. Schoenfeld, B.T. Thompson, N. Ringwood, C. Oldmixon, F. Molay, A. Korpak, R. Morse, D. Hayden, M. Ancukiewicz, A. Minihan; Protocol-Review Committee—J.G.N. Garcia, R. Balk, S. Emerson, M. Shasby, W.Sibbald; Data Safety and Monitoring Board: R. Spragg, G. Corbie-Smith, J. Kelley, K. Leeper, A.S. Slutsky, B. Turnbull, C. Vreim; ARDS Clinical Trials Network Consultant: P. Parsons; Clinical Centers are as follows: University of Washington, Harborview: L. Hudson, K. Steinberg, M. Neff, R. Maier, K. Sims, C. Cooper, T. Berry-Bell, G. Carter, L. Andersson; University of Michigan: G.B. Toews, R.H. Bartlett, C. Watts, R. Hyzy, D. Arnoldi, R. Dechert, M. Purple; University of Maryland: H. Silverman, C. Shanholtz, A. Moore, L. Heinrich, W. Corral; Johns Hopkins University: R. Brower, D. Thompson, H. Fessler, S. Murray, A. Sculley; Cleveland Clinic Foundation: H.P. Wiedemann, A.C. Arroliga, J. Komara, T. Isabella, M. Ferrari; University Hospitals of Cleveland: J. Kern, R. Hejal, D. Haney; MetroHealth Medical Center: A.F. Connors; University of Colorado Health Sciences Center: E. Abraham, R. McIntyre, F. Piedalue; Denver Veterans Affairs Medical Center: C. Welsh; Denver Health Medical Center: I. Douglas, R. Wolkin; St. Anthony Hospital: T. Bost, B. Sagel, A. Hawkes; Duke University: N. MacIntyre, J. Govert, W. Fulkerson, L. Mallatrat, L. Brown, S. Everett, E. VanDyne, N. Knudsen, M. Gentile; University of North Carolina: P. Rock, S. Carson, C. Schuler, L. Baker, V. Salo; Vanderbilt Universit: A.P. Wheeler, G. Bernard, T. Rice, S. Bozeman, T. Welch; University of Pennsylvania: P. Lanken, J. Christie, B. Fuchs, B Finkel, S. Kaplan, V. Gracias, C.W. Hanson, P. Reilly, M.B. Shapiro, R. Burke, E. O’Connor, D. Wolfe; Jefferson Medical College: J. Gottlieb, P. Park, D.M. Dillon, A. Girod, J. Furlong; LDS Hospital: A. Morris, C. Grissom, L. Weaver, J. Orme, T. Clemmer, R. Davis, J. Gleed, S. Pies, T. Graydon, S. Anderson, K. Bennion, P. Skinner; McKay-Dee Hospital: C. Lawton, J. d’Hulst, D. Hanselman; Utah Valley Regional Medical Center: K. Sundar, T. Hill, K. Ludwig, D. Nielson; University of California, San Francisco: M.A. Matthay, M. Eisner, B. Daniel, O. Garcia; San Francisco General: J. Luce, R. Kallet; University of California, San Francisco, Fresno: M. Peterson, J. Lanford; Baylor College of Medicine: K. Guntupalli, V. Bandi, C. Pope; Baystate Medical Center: J. Steingrub, M. Tidswell, L. Kozikowski; Louisiana State University Health Sciences Center: B. deBoisblanc, J. Hunt, C. Glynn, P. Lauto, G. Meyaski, C. Romaine; Louisiana State University Earl K. Long Center: S. Brierre, C. LeBlanc, K. Reed; Alton-Ochsner Clinic Foundation: D. Taylor, C. Thompson; Tulane University Medical Center: F. Simeone, M. Johnston, M. Wright; University of Chicago: G. Schmidt, J. Hall, S. Hemmann, B. Gehlbach, Vinayak, W. Schweickert; Northwestern University: J. Dematte D’Amico, H. Donnelly; University of Texas Health Sciences Center: A. Anzueto, J. McCarthy, S. Kucera, J. Peters, T. Houlihan, R. Steward, D. Vines; University of Virginia: J. Truwit, A.F. Connors, M. Marshall, W. Matsumura, R. Brett; University of Pittsburgh: M. Donahoe, P. Linden, J. Puyana, L. Lucht, A. Verno; Wake Forest University: R.D. Hite, P. Morris, A. Howard, A. Nesser, S. Perez; Moses Cone Memorial Hospital: P. Wright, C. Carter-Cole, J. McLean; St. Paul’s Hospital, Vancouver: J. Russell, L. Lazowski, K. Foley; Vancouver General Hospital: D. Chittock, L. Grandolfo; Mayo Foundation: M. Murray.
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