From the Center for Health Evaluation and Outcome Sciences (NJH), St Paul's Hospital, Vancouver, British Columbia Canada; the Center for Health Evaluation and Outcome Sciences and Department of Medicine (PD), St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada; Queens University (DH), Kingston, Ontario, Canada; McMaster University (DC), Hamilton, Ontario, Canada.; Dalhousie University (GR), Halifax, Nova Scotia Canada; the University of Alberta (DK), Edmonton, Alberta, Canada; Sunnybrook Hospital (CD, RF), University of Toronto, Toronto, Ontario Canada; and the Division of Critical Care Medicine (NA), University of British Columbia and Providence Health Care, British Columbia, Canada.
Supported by the Canadian Institutes of Health Research and Michael Smith Foundation for Health Research.
This work was performed at the Center for Health Evaluation and Outcome Sciences, St Paul's Hospital, Vancouver, British Columbia, Canada.
Dr. Heyland received funding from CIHR and the Michael Smith Foundation. The remaining authors have not disclosed any potential conflicts of interest.
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