From the Department of Anesthesiology and Intensive Care Therapy (PMS, ARC, AG, RSC, NCC, AB, TK, MGdA), Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Dresden, Germany; Departments of Anesthesia, Medicine, and Physiology (PMS), Interdepartmental Division of Critical Care Medicine, University of Toronto, Keenan Research Center in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada; Laboratory of Respiration Physiology (ARC), Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil; Institute of Anatomy (MK), Dresden University of Technology, Dresden, Germany; Institute of Pharmacology and Toxicology (CD, SU), University Hospital Aachen, Aachen, Germany; and Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate (PP), Universitá degli Studi di Genova, Genova, Italy.
Supported, in part, by grant GA 1256/1-1 of the German Research Foundation (DFG), Bonn, Germany. Dräger Medical kindly provided the ventilator used in this study.
P.M. Spieth, A.R. Carvalho, and A. Güldner contributed equally to this article.
All experimental work was performed by the Pulmonary Engineering Group at the Department of Anesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany.
Drs. Gama de Abreu, Spieth, and Koch were granted two patents on variable pressure support ventilation (noisy PSV). The remaining authors have not disclosed any potential conflicts of interest.
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