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Therapeutic hypothermia for acute myocardial infarction: Past, present, and future

Parham, William MD; Edelstein, Kalie BS; Unger, Barbara BSN; Mooney, Michael MD

doi: 10.1097/CCM.0b013e3181ab311d

Therapeutic hypothermia has been shown in randomized clinical trials to improve neurologic outcomes following cardiac arrest. Whether therapeutic hypothermia improves important outcomes after acute myocardial infarction is an area of active research. Here we review recent experimental and clinical data that examine whether therapeutic hypothermia can improve functional outcomes or mortality rate in acute myocardial infarction. We conclude that the available clinical evidence does not support therapeutic hypothermia as standard therapy for acute myocardial infarction.

From the Minneapolis Heart Institute and Abbott Northwestern Hospital, Minneapolis, MN.

Ms. Unger has received a grant from Medivance. The remaining authors have not disclosed any potential conflicts of interest.

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© 2009 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins