LABORATORY INVESTIGATIONS
Janiszewski, Mariano MD, PhD; do Carmo, Alípio O. PharmD, MSc; Pedro, Marcelo A. MD; Silva, Eliézer MD, PhD; Knobel, Elias MD; Laurindo, Francisco R. M. MD, PhD
From the Cellular Biology Laboratory (MJ, AOC) and Intensive Care Unit (MJ, AOC, MAP, ES, EK), Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Avenida Albert Einstein, São Paulo, Brazil; and the Vascular Biology Laboratory (FRML), Heart Institute (InCor), University of Sao Paulo School of Medicine, São Paulo, Brazil.
Supported, in part, by an Institutional Grant from Hospital Israelita Albert Einstein; by grant 02/13007-9 from Fundaçao de Amparo a Pesquisa do Estado de São Paulo, Brazil; and by Jose Eduardo Krieger, Heart Institute, University of Sao Paulo School of Medicine, who donated rabbit endothelial cells and rabbit aortic smooth muscle cell lines.
Platelet-derived exosome nicotinamide adenine dinucleotide phosphate oxidase activity seems to contribute to vascular cell apoptosis and may represent a new vascular redox-signaling pathway involved in the pathophysiology of sepsis.
doi: 10.1097/01.CCM.0000114829.17746.19