From the Division of Anaesthesia (JPC, DC, AKG, DKM), the Department of Neurosurgery (PSM, JDP), and the Wolfson Brain Imaging Centre (JPC, PSM, TDF, PS, FA, TD, SPMJD, GW, JCM, TAC, JCC, JDP, DKM), University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK.
Supported, in part, by the Medical Research Council, a Technology Foresight Award from the UK Government, and by a Royal College of Anaesthetists/British Journal of Anesthesia project grant. Dr. Coles was funded by a Research Training Fellowship from the Addenbrooke’s Charities and is currently a Wellcome Research Training Fellow. Dr. Minhas was supported by an MRC Clinical Research Training Fellowship, and Ms. Chatfield was supported by a grant from the Fund for Addenbrooke’s.
Address requests for reprints to: Jonathan P. Coles, FRCA, Box 93, Addenbrooke’s Hospital, Cambridge, CB2 2QQ, UK. E-mail: [email protected]
Hyperventilation increases the volume of severely hypoperfused tissue within the injured brain, despite improvements in cerebral perfusion pressure and intracranial pressure.