Clinical InvestigationsRefractory delirium tremens treated with propofol: A case seriesMcCowan, Christy MD; Marik, Paul MD, FCCMAuthor Information From the Department of Emergency Medicine (Dr. McCowan), University of Massachusetts Medical Center, Worcester, MA; and the Department of Internal Medicine, Section of Critical Care (Dr. Marik), Washington Hospital Center, Washington, DC. Critical Care Medicine: June 2000 - Volume 28 - Issue 6 - p 1781-1784 Buy Abstract Delirium tremens, the most serious manifestation of alcohol withdrawal, occurs in ∼5% of hospitalized alcoholics and has a mortality rate approaching 15%. Patients with delirium tremens are usually treated in an intensive care unit in which benzodiazepines form the cornerstone of therapy. In this report, we describe four patients who proved refractory to high doses of benzodiazepines and were successfully treated with a propofol infusion. Copyright © by 2000 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.