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Evaluation of an antiseptic triple-lumen catheter in an intensive care unit

Hanley, Eileen M. BA; Veeder, Abigail BS; Smith, Thomas MD; Drusano, George MD; Currie, Eleanor MS; Venezia, Richard A. PhD

Clinical Investigations

Objective: To evaluate a decrease in catheter-related bloodstream infection rate in patients with antiseptic triple-lumen catheters in an intensive care unit.

Data Sources: Retrospective review of surveillance records, patient medical records, laboratory and microbiological reports, and antibiotic administration records.

Study Selection: Patients admitted to the intensive care unit with triple-lumen catheters.

Data Extraction: A subset of one entry per patient was extracted from 2 yrs of primary bloodstream infection surveillance data. Data collection included risk factors, laboratory and microbiological data, and insertion sites and dates of all intravascular catheters present during triple-lumen catheterization.

Data Synthesis: The catheter-related bloodstream infection rate was 5.4 and 11.3 per 1000 catheter days in antiseptic and nonantiseptic triple-lumen catheter groups, respectively (p= .06). By multivariate analysis using a Cox Proportional Hazards Model, the antiseptic triple-lumen catheters were associated with a significant reduction in catheter-related bloodstream infection (p= .03). Model expansion to include intrajugular site was significant by a likelihood ratio test [2(log likelihood diff) = 4.26p< .05 χ21]

Conclusions: The use of antiseptic triple-lumen catheters may substantially reduce catheter-related bloodstream infections in an intensive care population and may be subsequently associated with a decrease in length of stay.

From the Department of Epidemiology, Albany Medical Center Hospital (Ms. Hanley, Veeder, and Currie and Dr. Venezia) and the Department of Medicine, Albany Medical College (Drs. Smith and Drusano).

Presented, in part, at the 37th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, October 1997, Toronto, Canada.

Supported, in part, by Arrow International, Reading, Pennsylvania.

Address request for reprints to: Eileen M. Hanley, Department of Epidemiology A-45, Albany Medical Center Hospital, New Scotland Avenue, Albany, New York 12208

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