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Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: An immunologic evaluation of Impact Registered Trademark

Kemen, Matthias MD; Senkal, Metin MD; Homann, Heinz-Herbert MD; Mumme, Achim MD; Dauphin, Anne-Kathrin MD; Baier, Jurgen MD; Windeler, Jurgen MD; Neumann, Herbert MD; Zumtobel, Volker MD

Clinical Investigation

Objective To evaluate the effect of early postoperative feeding with a nutritionally complete enteral diet supplemented with the nutrients arginine, ribonucleic acid (RNA), and omega-3 fatty acids on the immune function in patients undergoing surgery for upper gastrointestinal (GI) malignancies.

Design Prospective, randomized, placebo-controlled, double-blind study.

Setting Surgical intensive care unit (ICU) in a German university hospital.

Patients Forty-two consecutive patients receiving an enteral diet via needle catheter jejunostomy after GI surgery for cancer.

Interventions Patients were randomized to receive either the arginine, RNA, and omega-3 fatty acids supplemented diet or an isocaloric and isonitrogenous placebo diet. Early enteral nutrition was started on postoperative day 1 in the surgical ICU with 20 mL/hr and progressed to the optimal goal of 80 mL/hr by postoperative day 5.

Measurements and Main Results Clinical examination and adverse GI symptoms were recorded on a daily basis. Body weight was determined twice weekly. Immunoglobulin concentrations were determined by laser nephelometry. Interferon-gamma concentrations were measured with a modified enzyme-linked immunosorbent assay method. Fluorescence-activated cell scan flow cytometry was performed to analyze B cells, T lymphocytes and their subsets. Clinical patient characteristics and mean caloric intake were similar between the two groups and both formulas were well tolerated. The number of T lymphocytes and their subsets, helper T cells (CD4) and activated T cells (CD3, HLA-DR), were significantly higher in the supplemented diet group on postoperative days 10 and 16 (p < .05). Mean interferon-gamma concentration after phytohemagglutinin stimulation was higher in the supplemented diet group on postoperative day 16. In the supplemented diet group, mean immunoglobulin M concentrations were significantly higher on postoperative day 10 and mean immunoglobulin G concentrations were higher on postoperative day 16 (p < .05) compared with the results in the placebo group. B-lymphocyte indices were significantly higher in the supplemented vs. the placebo diet group on postoperative days 7 and 10 (p < .05).

Conclusions Supplementation of enteral diet with arginine, RNA, and omega-3 fatty acids in the early postoperative time period improves postoperative immunologic responses and helps to overcome more rapidly the immunologic depression after surgical trauma.

(Crit Care Med 1995; 23:652-659)

From the Departments of Surgery (Drs. Kemen, Senkal, Homann, Mumme, Dauphin, and Zumtobel) and Medicine (Drs. Baier and Neumann), Ruhr-University Bochum, St. Josef Hospital; and the Institute of Medical Statistics (Dr. Windeler), Bochum, FRG.

This study was supported, in part, by Sandoz Nutrition, Bern, Switzerland.

Address requests for reprints to: Matthias Kemen, MD, Department of General Surgery, St. Josef Hospital, University Hospital of the Ruhr-University Bochum, Gudrunstr. 56, 44791 Bochum, FRG.

© Williams & Wilkins 1995. All Rights Reserved.