Effect of cocarboxylase in dogs subjected to experimental septic shockLINDENBAUM, GARY A. MD; LARRIEU, ALBERTO J. MD; CARROLL, STANTON F. MD; KAPUSNICK, REGINA A. BSCritical Care Medicine: October 1989 - Volume 17 - Issue 10 - p 1036–1040 laboratory investigations: PDF Only Buy Abstract Author InformationAuthors We examined the effects of cocarboxylase treatment on both the hemodynamic variables and metabolic function during endotoxic shock in dogs. Cocarboxylase inhibited deterioration in metabolic function as reflected by improved pH and base excess as well as maintenance of normal oxygen consumption. Significant improvements in mean arterial pressure and cardiac index were also seen. Cocarboxylase is a major coenzyme of mitochondrial pyruvate dehydrogenase and may exert its beneficial effects via this complex. (Crit Care Med 1989; 17:1036) From the Department of Surgery and Cardrothoracic Surgery Albert Einstein Medical Center. Philadelphia, PA. © Williams & Wilkins 1989. All Rights Reserved.