Laboratory Investigations: PDF OnlyRenal oxygenation in endotoxin shock in dogsGULLICHSEN, EERO MD, MSc; NELIMARKKA, OLAVI MD; HALKOLA, LAURI MSc; NIINIKOSKI, JUHA MD Author Information From the Department of Surgery and Cardiorespiratory Research Unit. University of Turku. Turku. Finland Critical Care Medicine: June 1989 - Volume 17 - Issue 6 - p 547-550 Buy Abstract Renal hemodynamics and oxygen metabolism were studied in eight adult beagle dogs during shock induced with an iv infusion of Escherichia coli endotoxin. Renal blood flow (RBF) and renal cortical Po2 decreased profoundly during the 15-min endotoxin infusion. RBF increased sharply immediately after cessation of infusion, but soon declined and remained depressed throughout the rest of the 4-h experiment. The renal cortical Po2 remained depressed for approximately 2 h and then gradually increased toward the baseline level. Endotoxin infusion was followed by an increased renal Po2 and a decreased renal arteriovenous oxygen difference. Renal oxygen consumption declined abruptly during endotoxin infusion, but increased toward the end of the experiment. These results suggest impaired tissue oxygenation and possibly increased oxygen shunting in the kidney during endotoxin shock. © Williams & Wilkins 1989. All Rights Reserved.
