Laboratory Investigations: PDF OnlyNeither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in pigletsRUDINSKY, BRIAN F. MD; KOMAR, KARL J. MD; STRATES, ELENE BA; MEADOW, WILLIAM L. MD, PHDAuthor Information From the Department of Pediatrics, Wyler Children's Hospital, University of Chicago, Chicago, IL. Critical Care Medicine: December 1987 - Volume 15 - Issue 12 - p 1127-1130 Buy Abstract No therapeutic agent consistently decreases pulmonary arterial pressure (PAP) more than aortic pressure in neonates with persistent pulmonary hypertension of the newborn. We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-induced pulmonary hypertension. Piglets were anesthetized, intubated, and ventilated. Pulmonary hypertension was induced by an iv infusion of group B Streptococci. Piglets were then divided into three groups with group B Streptococci infusion ongoing. Neither PAP nor the pulmonary vascular resistance index was decreased significantly by either NP or NG. NP decreased significantly both mean aortic pressure and the systemic vascular resistance index. Cardiac index decreased significantly during both NG and placebo infusion. These data suggest that neither NP nor NG is likely to be beneficial in sepsis-induced pulmonary hypertension in newborns. © Williams & Wilkins 1987. All Rights Reserved.