Renin-angiotensin System Blocker in COVID-19. A Single Center Study (Drs. Riya Job, Mohamed Abdul Qader, Pedro Torres, Baher Al Abbasi, Nakeya Dewaswala, Ahmed Abdallah, Kai Chen, Jesus E. Pino, Robert D. Chait). Early during the Covid-19 pandemic, concerns were raised regarding potential adverse outcomes in patients taking ACEIs/ARBs. These concerns were based on animal studies showing increased ACE-2 expression in mice treated with ACEI/ARB. This is a single-center retrospective cohort study of 289 patients diagnosed with 2019 Novel Coronavirus (SARS-CoV-2) hospitalized between March of 2020 and June of 2020. The study was intended to investigate the impact of ACEIs and/or ARBs on in-hospital mortality, intensive care unit (ICU) admission, post-admission hemodialysis requirement and the need for mechanical ventilation in patients with COVID-19…This study suggests that the use of ACEIs and ARBs in patients with COVID-19 was not found to significantly increase all-cause in-hospital mortality, ICU admissions, and hemodialysis and mechanical ventilation requirements.
