In the February issue, Dr. Peng Zhang and colleagues explore what is known and yet-to-be discovered about the protective role of H2S in the myocardium. This gaseous compound is reported to act through multiple mechanisms that, among others, are anti-apoptotic (e.g., inhibition of the mitochondrial pathway and ER stress), anti-oxidative stress, and preventive of Ca2+ overload. They also discuss the ongoing development and therapeutic potential of slow-release H2S donors and H2S-releasing hybrid drugs and the challenges involved. In the February issue, we also acknowledge the 232 individuals who reviewed manuscripts for the Journal in the period from July through December of 2020. Their hard work, time, and dedication to science are essential for maintaining the integrity of the Journal, and their selfless support is deeply appreciated.