Adrenergic Receptor Regulation of Mitochondrial Function in Cardiomyocytes: Erratum

In the September, 2022 issue of the Journal of Cardiovascular Pharmacology in the article by Sandroni et al, “Adrenergic Receptor Regulation of Mitochondrial Function in Cardiomyocytes,”¹ the numbered list of references provided for Table 1 is incorrect.

Please see the revised table below with the corrected list of references.

Table 1. - Summary of Adrenergic Regulation of Mitochondrial Function in Cardiomyocytes

	AR	Model	Intervention	Effect	Ref
Biogenesis	β2	Mouse; heart	Formoterol (100 µg/kg, 24 or 48 h)	↑ mtDNA ↑ PGC1α	69
	β	Mouse; adult rat cardiomyocytes	Isoproterenol (100 nM, 12–48 h)	No effect	70
	β	Mouse; heart	Isoproterenol (15 mg/kg, 14 d)	No effect	70
	β2	Mouse; left ventricle	Formoterol (0.3 mg/kg, 24 h)	No effect	71
	α1	Mouse; C2C12, HL-1	Midodrine (1–30 µM, 24 h)	↑ PGC1α expression	72
	α1	Rat; heart	Midodrine (0.3 mg/kg/d, 4 w)	↑ PGC1α	72
	α1A	Mice; heart	Dabuzalgron (20 µg/kg/d, 7 d)	↑ PGC1α expression	73
Dynamics	β	Rat; H9c2	Isoproterenol (10 µM, 30 min)	‒ fission ↑ Drp1 activation	84
	β	Rat; H9c2	Isoproterenol (1 µM, 24 h)	↑ fission	70
	β	Mouse; HL-1	Isoproterenol (10 µM, 1 h)	↑ fission ↑ Drp1 translocation	85
	β1*	Mouse; HL-1	Isoproterenol (10 µM, 1 h) + CGP20712A (300 nM)	↓ fission	85
	β2*	Mouse; HL-1	Isoproterenol (10 µM, 1 h) + ICI 118,551 (300 nM)	↑ fission	85
	β2*	Mouse; heart	β2 genetic deletion	↑ fission ↑ Drp1 translocation	85
	All	Rat; neonatal ventricular myocyte	Norepinephrine (10 µM, 2–48 h)	↑ fission	93
	α1*	Rat; neonatal ventricular myocyte	Norepinephrine (10 µM, 48 h) + Prazosin (1 µM)	↓ fission	93
	α1	Rat; H9c2	Phenylephrine (10 µM, 30 min)	↑ fission ↑ Drp1 activation	84
Mitochondrial Calcium	β	Mouse; adult left ventricular myocytes	Isoproterenol (500 nM, 5–20 min)	↑ mitochondrial calcium	86
	β	Rat; adult ventricular myocytes	Isoproterenol (100 nM, 10 min)	↑ mitochondrial calcium	126
	β	Mouse; adult ventricular myocytes	Isoproterenol (500 nM, 15 min)	↑ mitochondrial calcium	127
	β1	Mouse; adult cardiomyocytes	Dobutamine (32 ng/g/min, 30 min)	↑ mitochondrial calcium	131
	α1	Rat; heart	Methoxamine (10 µM, 2 min)	↑ mitochondrial calcium	134
	α1	Rat; H9c2	Phenylephrine (100 µM, 120 s)	↑ mitochondrial calcium	137
	α1	Rat; adult left ventricular myocytes	Phenylephrine (10 µM, 30 min)	↓ mitochondrial calcium	145
	α1B*	Rat; adult left ventricular myocytes	Phenylephrine (10 µM, 30 min) + CEC (1 mM)	↑ mitochondrial calcium	145
	α1A*	Rat; adult left ventricular myocytes	Phenylephrine (10 µM, 30 min) + 5-MU (10 µM)	↑ mitochondrial calcium	145
OXPHOS	All*	Mouse; embryos	AR genetic deletion	↓ ATP content ↓ ECA ↓ OCR	83
	β	Mouse; embryos	AR genetic deletion + Isoproterenol (maternal, 0.2 mg/mL, 2–3 w)	↑ ATP content ↑ ECA ↑ OCR	83
	α1	Mouse; embryos	AR genetic deletion + Phenylephrine (maternal, 0.2 mg/mL, 3 w)	↑ ATP content ↑ ECA ↑ OCR	83
	All	Rat; adult cardiomyocytes	Norepinephrine (1 µM, 5–120 min)	↑ superoxide production	154
	β	Mouse; HL-1	Isoproterenol (10 µM, 1 h)	↑ basal OCR ↑ maximal OCR ↑ ATP-linked OCR ↑ ATP production	85
	β1*	Mouse; HL-1	Isoproterenol (10 µM, 1 h) + GCP20712A (300 nM)	↓ basal OCR ↓ maximal OCR ↓ ATP-linked OCR ↓ ATP production	85
	β	Rat; H9c2	Isoproterenol (10 µM, 48 h)	↑ complex I activity	155
	β	Rabbit; cardiomyocytes	Isoproterenol (0.1 µM, 15 min)	↓ redox potential ↓ superoxide production	160
	β	Mouse; left ventricular myocytes	Isoproterenol (500 nM, 5–20 min)	↓ membrane potential ‒ superoxide production ‒ ATP production	127
	β	Mouse; neonatal mouse cardiomyocytes	Isoproterenol (10 µM, 5–120 min)	↑ superoxide production ‒ NAD+/NADH ratio	135
	β	Rat; adult cardiomyocytes	Isoproterenol (10 µM)	↑ complex V activity	162
	β2*	Mice; heart	β2 genetic deletion	↓ complex I activity ↓ complex II activity	65
	β2	Mouse; left ventricle	Formoterol (0.3 mg/kg, 24 h)	↑ complex I abundance	71
	β2	Mouse; heart	β2 overexpression (200-fold)	↓ ATP production	8
	β2*	Mouse; HL-1	ICI 118, 551 (300 nM)	↑ basal OCR ↑ maximal OCR ↑ ATP-linked OCR	85
	β2*	Mouse; cardiomyocytes	β2 genetic deletion	‒ OCR	85
	β2	Mouse; heart	Clenbuterol (1 mg/kg, 12 h)	↑ complex V activity ↑ ATP production	163
	α1	Rat; H9c2	Phenylephrine (100 µM, 1 h)	↑ basal OCR ↑ maximal OCR ↑ ATP-linked OCR ↑ reserve capacity ↑ superoxide production	84
	α1	Mouse; C2C12	Midodrine (30 µM, 24 h)	↑ OCR ↑ ATP content ↑ complex II activity ↑ complex IV density	72
	α1	Rat; H9c2	Midodrine (30 µM, 24 h)	↑ OCR ↑ ATP production	72
	α1A	Mouse; heart	Dabuzalgron (20 µg/kg/d, 7 d)	↑ ATP content ↑ complex I expression ↑ complex III expression ↑ complex V expression	73
	α1A	Rat; neonatal ventricular myocyte	Dabuzalgron (10 µM, 24 h)	↑ membrane potential	73

Increases (↑), decreases (↓), or no significant effect (−) are listed. (*) denotes decreased adrenergic receptor (AR) activation due to genetic deletion or antagonist treatment. Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC1α) regulates mitochondrial protein transcription and mitochondrial DNA (mtDNA) replication required for mitochondrial biogenesis. Dynamin-related protein 1 (Drp1) regulates fission. Oxygen consumption rate (OCR) and extracellular acidification (ECA) are metrics for oxidative phosphorylation (OXPHOS).