Two timely review articles appear in the March issue. One focuses on direct oral anticoagulants (DOACs), which are now first-line therapy for stroke prevention in non-valvular atrial fibrillation (AF) patients with high thromboembolic risk. This article by Melillo et al. provides an update on the practical aspects of their usage and clinical performance among AF patients undergoing different interventional procedures. Additionally, it explores the potential alternative therapeutic strategy of DOACs in cardiac interventional procedures among non-AF patients. The second review by Gu et al. examines the role of the transcription factor NFATc1 (nuclear factor of activated T cell cytoplasmic 1) as a common denominator and possible therapeutic target in osteoporosis and vascular calcification/coronary heart disease, which are commonly linked. We trust that our readers will enjoy both review articles, as well as the editorial commentary and six original articles in the March issue.