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Medical Misinformation

Vet the Message!

Hill, Joseph A., MD, PhD; Agewall, Stefan, MD, PhD; Baranchuk, Adrian, MD; Booz, George W., PhD; Borer, Jeffrey S., MD; Camici, Paolo G., MD; Chen, Peng-Sheng, MD; Dominiczak, Anna F., DBE, MD; Erol, Çetin, MD, PhD; Grines, Cindy L., MD; Gropler, Robert, MD; Guzik, Tomasz J., MD, PhD; Heinemann, Markus K., MD, PhD; Iskandrian, Ami E., MD; Knight, Bradley P., MD; London, Barry, MD, PhD; Lüscher, Thomas F., MD; Metra, Marco, MD; Musunuru, Kiran, MD, PhD, MPH; Nallamothu, Brahmajee K., MD, MPH; Natale, Andrea, MD; Saksena, Sanjeev, MD; Picard, Michael H., MD; Rao, Sunil V., MD; Remme, Willem J., MD, PhD; Rosenson, Robert S., MD; Sweitzer, Nancy K., MD, PhD; Timmis, Adam, MD; Vrints, Christiaan, MD, PhD

Journal of Cardiovascular Pharmacology: February 2019 - Volume 73 - Issue 2 - p 61–62
doi: 10.1097/FJC.0000000000000648

Joseph A. Hill, MD, PhD, University of Texas Southwestern Medical Center, Internal Medicine, NB11.200, UT Southwestern, 6000 Harry Hines Blvd, Dallas, TX 75390-8573 (email

P.G. Camici is consultant for Servier. R.S. Rosenson reports research grants to his institutions from Akcea, Amgen, Astra Zeneca, Medicines Company and Regeneron. R.S. Rosenson reports speaking engagements at Amgen and Kowa, research consulting for Akcea and Regeneron, royalties from UpToDate, Inc. and stock holdings in MediMergent. All other authors have nothing to disclose.

The members of the HEART Group Signatories are listed in Appendix 1.

A complete list of all journals publishing this article, along with links to the individual articles, can be found online at

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.

“Mrs. Jones, based on your risk factors for having a heart attack, I recommend that we start you on a statin.”

“No, thank you, doctor, I've read too many scary things about those drugs on the internet. Plus, I worry that some in your profession make these recommendations for reasons of personal financial gain. I also found that online.”

Undoubtedly, most cardiologists have had conversations just like this, urging a patient to take statin, which are a class of powerful cholesterol-lowering drugs with robust mortality benefit. Part of the reason these oftentimes “no brainer” recommendations are rejected derives from widely disseminated incorrect information, which vastly overstates the risks of these drugs (of course, like anything in life, statin use is not entirely risk-free; their application should always entail a thoughtful analysis of risks vs. benefits). Most patients do not recognize that the benefits of statin use are invisible (“I didn't have a heart attack or stroke this past year.”), whereas the small and typically reversible risks (eg, muscle pain) are readily apparent. Many patients who would benefit from statin use do not take them.

Cardiovascular disease is the #1 killer of both men and women around the world. Robust scientific advances, published in the pages of our journals, have fostered significant improvements that benefit individuals and society. Yet, cardiovascular disease continues to transform itself, emerging in new forms, such as heart failure. The struggle has shifted to new battlefields.

These successes derive from an armamentarium of powerful tools—medicines and devices—and awareness of lifestyle-related hazards, such as high blood pressure, high cholesterol, and smoking. Sadly, however, we do not take full advantage of the tools at our disposal.

One significant cause of suboptimal utilization of our prodigious tool chest is medical misinformation hyped through the internet, television, chat rooms, and social media. In many instances, celebrities, activists, and politicians convey false information; not uncommonly, authors with purely venal motives participate.

We can point to numerous other examples, including the entirely unfounded concerns regarding vaccinations. The notion that measles, mumps, rubella (MMR) vaccination causes autism was based on a single, flawed study, long since refuted and its publication retracted. Seventeen much larger and properly controlled studies have proven otherwise. Nevertheless, the internet shouts unfounded warnings. Once again, celebrities, actors, activists, and politicians with no specific knowledge or training use their fame to promote a message that causes serious harm. Individuals who are neither physicians nor scientists, but often with a specific agenda, have outsized influence over our lives. They dispute scientific evidence without ever having studied it.1

Recognizing that it is impossible to prove “never,” scientists appropriately couch their statements in statistical terms, which may come across to the public as equivocation. The nuanced voices of scientists often do not resonate with the public as much as the strident alarms sounded by people of fame, speaking in absolute terms.

Furthermore, scientists are appropriately skeptical because any individual scientist or study can be wrong. Yet, science ultimately self-corrects. When a scientist gets it wrong, as happens, people sometimes vilify the entire, self-correcting scientific enterprise. We trust aeronautical science when we board an airplane; we trust the science buried within our cell phones; we trust mechanical engineering science when we cross a bridge; yet, many are uniquely skeptical of biological science.

Sadly, we cannot exclude that some in the professions of science and medicine act based on motives driven by financial considerations; incomplete declarations of potential conflict of interest persist.2 Recent examples of dramatic price hikes for important medications have reinforced this notion. Indeed, many physicians have had conversations with patients who believe that our recommendations stem, at least in part, from the prospect of personal financial gain.

We, the editors-in-chief of the major cardiovascular scientific journals around the globe, sound the alarm that human lives are at stake. Pointing to the 2 examples elaborated above, people who decline to use a statin when recommended by their doctor, or parents who withhold vaccines from their children, put lives in harm's way.

The media must do a better job. It is unacceptable to posit false equivalents in these discussions, often done to foster debate and controversy. It is easy to find a rogue voice but inappropriate to suggest that voice carries the same weight as that emerging from mainstream science (we can easily point to examples outside the medical domain, as well, such as climate change, evolution, nutraceuticals, and GMO foods where false equivalents are frequently posited). Furthermore, recent evidence suggests that misinformation travels faster through social networks than truth.3 We must work to enhance science literacy in our world; one place to start is by doing a better job of teaching the scientific method in our schools so that the lay public is aware that science is accomplished in fits and starts, but in the end, gets it right.

Purveyors of social media must be responsible for the content they disseminate. It is no longer acceptable to hide behind the cloak of “platform.” We, as editors, are charged with evaluating the validity of the science presented to us for possible publication, and we work hard to fulfill this heady responsibility. Recognizing that lives are at stake, we reach out to thought-leading experts to evaluate the veracity of each report we receive. Here, we challenge social media to do the same, to leverage the ready availability of science-conversant expertise before disseminating content that may not be reliable.

Without exaggeration, significant harm, to society and individuals, derives from the wanton spread of medical misinformation. It is high time that this stops, and we lay at the feet of the purveyors of internet and social media content the responsibility to fix this.

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Members of HEART Group Signatories

Joseph A. Hill, MD, PhD: Editor-in-Chief, Circulation. Stefan Agewall, MD, PhD: Editor-in-Chief, European Heart Journal Cardiovascular Pharmacotherapy. Adrian Baranchuk, MD: Editor-in-Chief, Journal of Electrocardiology. George W. Booz, PhD: Editor-in-Chief, Journal of Cardiovascular Pharmacology. Jeffrey S. Borer, MD: Editor-in-Chief, Cardiology. Paolo G. Camici, MD: Editor-in-Chief, International Journal of Cardiology. Peng-Sheng Chen, MD: Editor-in-Chief, HeartRhythm. Anna F. Dominiczak, DBE, MD: Editor-in-Chief, Hypertension. Çetin Erol, MD, PhD: Editor-in-Chief, Anatolian Journal of Cardiology. Cindy L. Grines, MD: Editor-in-Chief, Journal of Interventional Cardiology. Robert Gropler, MD: Editor-in-Chief, Circulation: Cardiovascular Imaging. Tomasz J. Guzik, MD, PhD: Editor-in-Chief, Cardiovascular Research. Markus K. Heinemann, MD, PhD: Editor-in-Chief, The Thoracic and Cardiovascular Surgeon. Ami E. Iskandrian, MD: Editor-in-Chief, Journal Nuclear Cardiology. Bradley P. Knight, MD: Editor-in-Chief, PACE and EPLab Digest. Barry London, MD, PhD: Editor-in-Chief, Journal of the American Heart Association. Thomas F. Lüscher, MD: Editor-in-Chief, European Heart Journal. Marco Metra, MD: Editor-in-Chief, European Journal of Heart Failure. Kiran Musunuru, MD, PhD, MPH: Editor-in-Chief, Circulation: Genomic and Precision Medicine. Brahmajee K. Nallamothu, MD, MPH: Editor-in-Chief, Circulation: Cardiovascular Quality and Outcomes. Andrea Natale, MD, Sanjeev Saksena, MD: Editors-in-Chief, Journal of Interventional Cardiac Electrophysiology. Michael H. Picard, MD: Editor-in-Chief, Journal of the American Society of Echocardiography. Sunil V. Rao, MD: Editor-in-Chief, Circulation: Cardiovascular Interventions. Willem J. Remme, MD, PhD, Robert S. Rosenson, MD: Editors-in-Chief, Cardiovascular Drugs and Therapy. Nancy K. Sweitzer, MD, PhD: Editor-in-Chief, Circulation: Heart Failure. Adam Timmis, MD: Editor-in-Chief, European Heart Journal: Quality of Care and Clinical Outcomes. Christiaan Vrints, MD, PhD: Editor in Chief, European Heart Journal: Acute Cardiovascular Care.

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1. Offit PA. Bad Advice: Columbia University Press; 2018.
2. Orenstein C, Thomas K. Top cancer researcher fails to disclose corporate financial ties in major research journals. New York Times. Available at: Accessed September 8, 2018.
3. Vosoughi S, Roy D, Aral S. The spread of true and false news online. Science 2018;359:1146–1151.
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