Review ArticleDiagnosis and Treatment of Intracardiac ThrombusPatel, Murti MD*; Wei, Xin MD†; Weigel, Kylie PharmD‡; Gertz, Zachary M. MD†; Kron, Jordana MD†; Robinson, Austin A. MD§; Trankle, Cory R. MD†Author Information *Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA; †Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA; ‡School of Pharmacy, Virginia Commonwealth University, Richmond, VA; and §Division of Cardiology, Scripps Clinic, La Jolla, CA. Correspondence: Cory R. Trankle, MD, VCU Pauley Heart Center, Virginia Commonwealth University, PO Box 980036, 1200E Broad St, Richmond, VA 23298 (e-mail: [email protected]). The authors report no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jcvp.org). M. Patel and X. Wei authors contributed equally to the realization of this manuscript. Journal of Cardiovascular Pharmacology: September 2021 - Volume 78 - Issue 3 - p 361-371 doi: 10.1097/FJC.0000000000001064 Buy SDC Metrics Abstract Intracardiac thrombi can occur in a variety of locations and are frequently encountered in clinical practice. Yet evidence-based guidance for clinicians managing patients with intracardiac thrombi is often limited. This review summarizes what is known regarding the prevalence of intracardiac thrombus, diagnostic strategies, clinical relevance, and treatment options, focusing on four specific types of thrombus for which recent research has shifted clinical understanding and treatment decisions: (1) left atrial appendage thrombus, (2) cardiac implantable electronic device lead thrombus, (3) bioprosthetic aortic valve thrombus, and (4) left ventricular thrombus. Additional studies, ideally prospective, randomized, and head-to-head in design, are needed to better inform best practices in patients with intracardiac thrombi. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.