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Third-hand Smoke: Impact on Hemostasis and Thrombogenesis

Karim, Zubair A. PhD*; Alshbool, Fatima Z. PharmD, PhD*; Vemana, Hari Priya BSc*; Adhami, Neema BSc; Dhall, Sandeep PhD; Espinosa, Enma V. P. MD, PhD*; Martins-Green, Manuela PhD; Khasawneh, Fadi T. PhD*

Journal of Cardiovascular Pharmacology: August 2015 - Volume 66 - Issue 2 - p 177–182
doi: 10.1097/FJC.0000000000000260
Original Article

Abstract: Cigarette smoking is a major risk factor for acute coronary thrombosis. In fact, both active/first-hand smoke and passive/second-hand smoke exposure are known to increase the risk of coronary thrombosis. Although recently a new risk has been identified and termed third-hand smoke (THS), which is the residual tobacco smoke contaminant that remains after a cigarette is extinguished, it remains to be determined whether it can also enhance the risk of thrombogenesis, much like first-hand smoke and second-hand smoke. Therefore, the present studies investigated the impact of THS exposure in the context of platelet biology and related disease states. It was found that THS-exposed mice exhibited an enhanced platelet aggregation and secretion responses as well as enhanced integrin GPIIb-IIIa activation. Furthermore, it was found that THS exposure shortens the tail bleeding time and the occlusion time in a model of thrombosis. Thus, our data demonstrate for the first time (at least in mice) that THS exposure increases the risk of thrombosis-based disease states, which is attributed, at least in part, to their hyperactive platelets.

*Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA; and

Department of Cell Biology and Neuroscience, University of California, Riverside, CA.

Reprints: Fadi T. Khasawneh, PhD, Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 E. Second St, Pomona, CA 91766 (e-mail: fkhasawneh@westernu.edu).

Supported by funds from the College of Pharmacy, Western University of Health Sciences, Pomona, CA (F.T.K.), and the Tobacco-Related Disease Research Program (19XT-0166; M.M.-G.).

The authors report no conflicts of interest.

Received February 01, 2015

Accepted March 18, 2015

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.