Review Article: PDF OnlyRole of circadian rhythm and impact of circadian rhythm disturbance on the metabolism and diseaseHan, Hui M Med1; Dou, Jinming M Med2; Hou, Qingqing M Med3; Wang, Huanjun M Med4Author Information 1School of Health, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China 2Department of Pediatrics, the 960 Hospital of the People's Liberation Army, Jinan 250031, Shandong, China 3School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China 4College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China Correspondence Author: Huanjun Wang M Med, College of Traditional Chinese Medicine, Office: 0531-89628207, Email: [email protected] Conflicts of Interest: None Journal of Cardiovascular Pharmacology: November 25, 2021 - Volume - Issue - doi: 10.1097/FJC.0000000000001178 Buy PAP Metrics Abstract Molecular circadian clocks exist in almost all cells of the organism and operate for approximately 24 h, maintain the normal physiological and behavioral body processes and regulate metabolism of many cells related to a variety of disease states. Circadian rhythms regulate metabolism, mainly including neurotransmitters, hormones, amino acids and lipids. Circadian misalignment is related to metabolic syndromes, such as obesity, diabetes and hypertension, which have reached an alarming level in modern society. We reviewed the mechanism of the circadian clock and the interaction between circadian rhythm and metabolism, as well as circadian rhythm disturbance on the metabolism of hypertension, obesity and diabetes. Finally, we discuss how to use the circadian rhythm to prevent diseases. Thus, this review is a micro to macro discussion from the perspective of circadian rhythm and aims to provide basic ideas for circadian rhythm research and disease therapies. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.