Drugs in the Pipeline – Review ArticleUltrasound and Magnetic Responsive Drug Delivery Systems for Cardiovascular ApplicationQian, Bei BMed; Zhao, Qiang MD; Ye, Xiaofeng PhDAuthor Information Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Reprints: Qiang Zhao, MD or Xiaofeng Ye, PhD, Department of Cardiac Surgery, Ruijin Hospital, No. 197 Ruijin Er Rd, Shanghai 200025, China (e-mail: firstname.lastname@example.org or email@example.com). The authors report no conflicts of interest. Journal of Cardiovascular Pharmacology: October 2020 - Volume 76 - Issue 4 - p 414-426 doi: 10.1097/FJC.0000000000000885 Buy Metrics Abstract With the increasing insight into molecular mechanisms of cardiovascular disease, a promising solution involves directly delivering genes, cells, and chemicals to the infarcted myocardium or impaired endothelium. However, the limited delivery efficiency after administration fails to reach the therapeutic dose and the adverse off-target effect even causes serious safety concerns. Controlled drug release via external stimuli seems to be a promising method to overcome the drawbacks of conventional drug delivery systems (DDSs). Microbubbles and magnetic nanoparticles responding to ultrasound and magnetic fields respectively have been developed as an important component of novel DDSs. In particular, several attempts have also been made for the design and fabrication of dual-responsive DDS. This review presents the recent advances in the ultrasound and magnetic fields responsive DDSs in cardiovascular application, followed by their current problems and future reformation. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.