Review ArticleTherapeutic Implications of Nitrite in HypertensionLing, Wei Chih PhD*; Mustafa, Mohd Rais PhD†; Murugan, Dharmani Devi PhD†Author Information *Department of Pre-clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor; and †Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Reprints: Dharmani Devi Murugan, PhD, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia (e-mail: firstname.lastname@example.org). The authors report no conflicts of interest. Received May 09, 2019 Accepted September 28, 2019 Journal of Cardiovascular Pharmacology: February 2020 - Volume 75 - Issue 2 - p 123-134 doi: 10.1097/FJC.0000000000000771 Buy Metrics Abstract Nitrite, an anion produced from the oxidative breakdown of nitric oxide (NO), has traditionally been viewed as an inert molecule. However, this dogma has been challenged with the findings that nitrite can be readily reduced to NO under pathological conditions, hence representing a physiologically relevant storage reservoir of NO either in the blood or tissues. Nitrite administration has been demonstrated to improve myocardial function in subjects with heart failure and to lower the blood pressure in hypertensive subjects. Thus, extensive amount of work has since been carried out to investigate the therapeutic potential of nitrite in treating cardiovascular diseases, especially hypertension. Studies done on several animal models of hypertension have demonstrated the efficacy of nitrite in preventing and ameliorating the pathological changes associated with the disease. This brief review of the current findings aims to re-evaluate the use of nitrite for the treatment of hypertension and in particular to highlight its role in improving endothelial function. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.