Matrix mineralization can be divided into physiological mineralization and pathological mineralization. There is a consensus among existing studies that matrix vesicles (MVs) are the starting sites of bone mineralization, and each component of MVs serves a certain function in mineralization. In addition, ectopic MVs pathologically promote undesired calcification, the primary focus of which is the promotion of vascular calcification. However, the specific mechanisms of the actions of MVs in bone–vascular axis cross-talk have not been fully elucidated. This review summarizes the latest research in this field and explores the roles of MVs in the bone–vascular axis with the aim of generating new ideas for the prevention and treatment of vascular calcification and bone metabolic disease.
*Departments of Cardiology; and
†Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Reprints: Zhongqun Wang, PhD, Department of Cardiology, Affiliated Hospital of Jiangsu University, 3rd Floor of Medical Technology Building, 438 Jiefang Rd, Zhenjiang, Jiangsu 212001 China (e-mail: firstname.lastname@example.org).
Supported by the following foundations: The National Natural Science Foundation of China (grant nos. 81770450, 81370408, 81670415), the related Projects of Jiangsu Province (QNRC20168 36, WSN-044, LGY2018092) and Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX18_0754), Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJKY19_2585), Social Development Foundation of Zhenjiang (SH2017031).
The authors report no conflicts of interest.
All authors contributed to conception and design and wrote the review. All authors read and approved the final manuscript.
Received March 26, 2019
Accepted June 24, 2019