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Efficacy and Safety of Loading Doses With P2Y12-Receptor Antagonists in Patients Without Dual Antiplatelet Therapy Undergoing Elective Coronary Intervention

Piqueras-Flores, Jesús, MD, PhD*; Jurado-Román, Alfonso, MD, PhD; López-Lluva, María Thiscal, MD; Sánchez-Pérez, Ignacio, MD; Abellán-Huerta, José, MD, PhD; Lozano-Ruiz Poveda, Fernando, MD, PhD

Journal of Cardiovascular Pharmacology: January 2019 - Volume 73 - Issue 1 - p 56–59
doi: 10.1097/FJC.0000000000000632
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Background: European Guidelines on Myocardial Revascularization recommend clopidogrel loading dose added to acetylsalicylic acid in elective percutaneous coronary interventions (PCIs). However, there is few evidence supporting this recommendation and other P2Y12 inhibitors have not been tested in these patients.

Purpose: To evaluate the effectiveness and safety of different loading doses of clopidogrel and ticagrelor in patients without double antiplatelet therapy and stable coronary artery disease (SCAD) undergoing elective PCI.

Methods: Retrospective study of 147 consecutive patients with SCAD undergoing elective PCI. Loading P2Y12 inhibitor doses evaluated were: clopidogrel 600 mg, clopidogrel 300 mg, clopidogrel 150 mg, and ticagrelor 180 mg. We analyzed the occurrence of major adverse cardiovascular events and periprocedural myocardial infarction.

Results: One hundred twenty-five patients were treated with clopidogrel (16 with clopidogrel 150 mg, 7 with clopidogrel 300 mg, and 93 with clopidogrel 600 mg) and 21 with ticagrelor 180 mg at the catheterization laboratory. The ticagrelor group had a significantly lower postprocedural peak of troponin-I (0.7 ± 3.4 vs. 0.3 ± 0.7 ng/mL; P = 0.02). There were no differences between groups in terms of major bleeding and hemoglobin drop after PCI (0.6 ± 0.8 vs. 4 ± 0.6; P = 0.8). The median of follow-up was 17 months (interquartile range 9–32.7). At the end of follow-up, major adverse cardiovascular event rate was not different between groups.

Conclusions: In patients without dual antiplatelet therapy undergoing elective PCI, the use of ticagrelor showed lower postprocedural myocardial injury without more bleeding complications.

*Cardiology Department, University General Hospital of Ciudad Real, Ciudad Real, Spain; and

Interventional Cardiology Department, University General Hospital of Ciudad Real, Ciudad Real, Spain.

Reprints: Jesús Piqueras-Flores, MD, PhD, Avenida Obispo Rafael Torija, 13005 Ciudad Real, Spain (e-mail: jesus.piqueras.flores@gmail.com).

The authors report no conflicts of interest.

J. Piqueras-Flores and A. Jurado-Román share the first authorship of the article.

Received July 23, 2018

Accepted September 26, 2018

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