Original ArticleEffects of Resistance Exercise Training on Doxorubicin-Induced CardiotoxicityPfannenstiel, Keith PhD*; Hayward, Reid PhD†Author Information *Department of Health, Physical Education, Recreation, Emporia State University, Emporia, KS; and †School of Sport and Exercise Science, University of Northern Colorado Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO. Reprints: Reid Hayward, University of Northern Colorado, Greeley, CO 80639 (e-mail: [email protected]). The authors report no conflicts of interest. R. Hayward is a Professor of Exercise Science in the School of Sport and Exercise Science at the University of Northern Colorado. He is also the Director of the University of Northern Colorado Cancer Rehabilitation Institute. Journal of Cardiovascular Pharmacology: June 2018 - Volume 71 - Issue 6 - p 332-339 doi: 10.1097/FJC.0000000000000574 Buy Metrics Abstract Although highly effective, doxorubicin (DOX) use is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether resistance training (RT) would protect against DOX-induced cardiac dysfunction and determine whether any observed functional preservation is a result of reduced lipid peroxidation or a preservation of the cardiac myosin heavy chain (MHC) isoform distribution. Rats were resistance-trained or remained sedentary for 12 weeks, then treated with 12.5 mg/kg DOX or 0.9% saline. Five days after DOX exposure, cardiac function, lipid peroxidation, and MHC isoform expression were quantified. RT preserved cardiac function and attenuated the α-to β-MHC shift that occurs with DOX treatment. No significant differences in lipid peroxidation were observed between sedentary and RT animals treated with DOX. These data suggest that resistance-type exercise can provide protection against DOX-induced cardiac dysfunction, which may be a result of a preservation of the cardiac MHC isoform distribution. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.